Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.40 |
| ▸ | ATM | Q13315 | 2/20 | 0.40 |
| ▸ | CNR2 | P34972 | 6/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.39 |
| ▸ | MEN1 | O00255 | 5/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | CNR1 | P21554 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9220169 | 0.88 | LMNA (0.43) | LMNAMAPK1TDP1L3MBTL1ATM | |
| SCHEMBL9212799 | 0.84 | LMNA (0.48) | LMNAMAPK1TDP1L3MBTL1ATM | |
| SCHEMBL9219336 | 0.80 | MAPK1 (0.44) | LMNAMAPK1TDP1L3MBTL1ATM | |
| SCHEMBL9211088 | 0.77 | MAPK1 (0.41) | LMNAMAPK1TDP1L3MBTL1ATM | |
| SCHEMBL9211091 | 0.77 | MAPK1 (0.41) | LMNAMAPK1TDP1L3MBTL1ATM | |
| SCHEMBL9380510 | 0.72 | LMNA (0.44) | LMNAMAPK1TDP1L3MBTL1ATM | |
| SCHEMBL9033191 | 0.72 | LMNA (0.44) | LMNAMAPK1TDP1L3MBTL1ATM | |
| SCHEMBL9216484 | 0.71 | LMNA (0.46) | LMNAMAPK1TDP1L3MBTL1ATM | |
| SCHEMBL8323182 | 0.70 | TUBB4A (0.48) | LMNAMAPK1TDP1L3MBTL1ATM | |
| SCHEMBL27559507 | 0.69 | LMNA (0.47) | LMNAMAPK1TDP1L3MBTL1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0433233-B1 | Heterocyclic compounds | CIBA GEIGY AG (CH) | 1995-01-25 | — | — | EP | claimed |
| EP-0433233-A1 | Heterocyclic compounds | CIBA-GEIGY AG (CH) | 1991-06-19 | — | — | EP | claimed |
| EP-0433233-B1 | Heterocyclic compounds | CIBA GEIGY AG (CH) | 1995-01-25 | — | — | EP | disclosed |
| US-5376677-A | Fungicides | CIBA-GEIGY CORPORATION (US) | 1994-12-27 | — | — | US | disclosed |
| EP-0433233-A1 | Heterocyclic compounds | CIBA-GEIGY AG (CH) | 1991-06-19 | — | — | EP | disclosed |