Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 2/20 | 0.43 |
| ▸ | CES2 | O00748 | 2/20 | 0.42 |
| ▸ | CES1 | P23141 | 2/20 | 0.42 |
| ▸ | SOAT1 | P35610 | 4/20 | 0.42 |
| ▸ | SOAT2 | O75908 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.40 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.40 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.40 |
| ▸ | ASAH1 | Q13510 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9214756 | 1.00 | EPHX2 (0.43) | EPHX2CES2CES1SOAT1SOAT2 | |
| SCHEMBL9829636 | 0.77 | ALOX5 (0.46) | CES2CES1 | |
| SCHEMBL9829630 | 0.77 | ALOX5 (0.46) | CES2CES1 | |
| SCHEMBL9829583 | 0.75 | CXCR2 (0.42) | KMT2A | |
| SCHEMBL9829581 | 0.75 | CXCR2 (0.42) | KMT2A | |
| SCHEMBL10440896 | 0.74 | POLB (0.48) | MEN1KMT2A | |
| SCHEMBL9214760 | 0.74 | HDAC6 (0.41) | EPHX2MEN1KMT2A | |
| SCHEMBL18112741 | 0.73 | KMT2A (0.43) | MEN1KMT2A | |
| SCHEMBL193093 | 0.72 | KCNN4 (0.44) | CES1MEN1KMT2A | |
| SCHEMBL3923935 | 0.72 | POLB (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0499521-B1 | Inhibitors of N-myristoyltransferase, their preparation process and pharmaceutical compositions containing them | ADIR (FR) | 1995-06-14 | — | — | EP | disclosed |
| EP-0499521-A1 | Inhibitors of N-myristoyltransferase, their preparation process and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1992-08-19 | — | — | EP | disclosed |