Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CPA3 | P15088 | 1/20 | 0.41 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.40 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | EPOR | P19235 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | APEX1 | P27695 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9214861 | 1.00 | CPA3 (0.41) | CPA3NR4A2TRPM8ADRA2CALDH1A1 | |
| SCHEMBL1083608 | 0.81 | CPA3 (0.42) | CPA3NR4A2TRPM8ADRA2CALDH1A1 | |
| SCHEMBL1083606 | 0.81 | CPA3 (0.42) | CPA3NR4A2TRPM8ADRA2CALDH1A1 | |
| SCHEMBL28129663 | 0.78 | FOLH1 (0.47) | CPA3NR4A2ALDH1A1CYP2D6CYP2C19 | |
| SCHEMBL4775104 | 0.78 | CPA3 (0.42) | CPA3NR4A2ALDH1A1CYP2D6CYP2C19 | |
| SCHEMBL28129661 | 0.78 | FOLH1 (0.47) | CPA3NR4A2ALDH1A1CYP2D6CYP2C19 | |
| SCHEMBL31266570 | 0.78 | CPA3 (0.42) | CPA3NR4A2ALDH1A1CYP2D6CYP2C19 | |
| SCHEMBL28797503 | 0.78 | CPA3 (0.42) | CPA3NR4A2ALDH1A1CYP2D6CYP2C19 | |
| SCHEMBL27805475 | 0.77 | TRPM8 (0.46) | NR4A2TRPM8ALDH1A1CYP2D6CYP2C19 | |
| SCHEMBL6304327 | 0.75 | LMNA (0.37) | ALDH1A1CYP2D6CYP2C19CYP1A2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2104587-A | — | — | None | — | — | JP | disclosed |
| EP-0344922-B1 | N-(N-(tetrahydropyrido(2,3-d)pyrimidinylmethyl)-aminomethylbenzoyl)glutamic acid derivatives | UNIV PRINCETON (US) | 1995-10-18 | — | — | EP | disclosed |
| EP-0344922-A3 | N-(N-(TETRAHYDROPYRIDO(2,3-D)PYRIMIDINYLMETHYL)-AMINOMETHYLBENZOYL)GLUTAMIC ACID DERIVATIVES | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1991-06-05 | — | — | EP | disclosed |
| JP-H02104587-A | N-(N-(TETRAHYDROPYRIDO(2,3-D)PYRIMIDINYLMETHYL) AMINOMETHYLBENZOYL)GLUTAMIC ACID DERIVATIVE | UNIV PRINCETON | 1990-04-17 | — | — | JP | disclosed |
| EP-0344922-A2 | N-(N-(tetrahydropyrido(2,3-d)pyrimidinylmethyl)-aminomethylbenzoyl)glutamic acid derivatives | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1989-12-06 | — | — | EP | disclosed |
| EP-0344922-A2 | N-(N-(tetrahydropyrido(2,3-d)pyrimidinylmethyl)-aminomethylbenzoyl)glutamic acid derivatives | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1989-12-06 | — | — | EP | disclosed |
| US-4871746-A | N-[N-(tetrahydropyrido[2,3-D]pyrimidinylmethyl)-aminomethylbenzoyl]glutamic acid derivatives as neoplastic growth inhibitors | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1989-10-03 | — | — | US | disclosed |
| US-4871746-A | N-[N-(tetrahydropyrido[2,3-D]pyrimidinylmethyl)-aminomethylbenzoyl]glutamic acid derivatives as neoplastic growth inhibitors | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1989-10-03 | — | — | US | disclosed |