SCHEMBL9214930

SCHEMBL9214930

O=c1[nH]c2c3c(cccn3c1=O)CC=C2

nearest known ligand 0.35

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PARP1 P09874 1/20 0.35
TP53 P04637 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL9598768 0.98 PARP1 (0.34) PARP1TP53
SCHEMBL3411010 0.64
SCHEMBL9155013 0.58 PARP1 (0.45) PARP1TP53
SCHEMBL25296578 0.55 PARP1 (0.32) PARP1
SCHEMBL1133601 0.52 PARP1 (1.00) PARP1TP53
SCHEMBL6136738 0.52 AHR (0.48)
SCHEMBL50865 0.52 MAOA (0.50) PARP1
SCHEMBL6643583 0.52 CYP1A2 (0.37)
SCHEMBL30252635 0.52 MAOA (0.50) PARP1
Hydrochloric Acid SCHEMBL2710069 0.51 MAOA (0.48) PARP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11002524-B2 Cyclic compounds and process for the preparation thereof COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) 2021-05-11 US disclosed
US-20200249002-A9 A CYCLIC COMPOUNDS AND PROCESS FOR THE PREPARATION THEREOF COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) 2020-08-06 US disclosed
EP-3436454-A1 A CYCLIC COMPOUNDS AND PROCESS FOR THE PREPARATION THEREOF Council of Scientific and Industrial Research (IN) 2019-02-06 EP disclosed
EP-3019498-B1 NOVEL TRICYCLIC COMPOUNDS AND PROCESS FOR PREPARATION THEREOF COUNCIL SCIENT IND RES (IN) 2018-12-26 EP disclosed
US-9822113-B2 Tricyclic compounds and process for preparation thereof COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) 2017-11-21 US disclosed
WO-2017168447-A1 A CYCLIC COMPOUNDS AND PROCESS FOR THE PREPARATION THEREOF COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) 2017-10-05 WO disclosed
US-20160152616-A1 NOVEL TRICYCLIC COMPOUNDS AND PROCESS FOR PREPARATION THEREOF COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) 2016-06-02 US disclosed
EP-0642508-A1 TRICYCLIC QUINOXALINEDIONES AS GLUTAMATE RECEPTOR ANTAGONISTS SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) 1995-03-15 EP disclosed
WO-1993008188-A1 TRICYCLIC QUINOXALINEDIONES AS GLUTAMATE RECEPTOR ANTAGONISTS SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) 1993-04-29 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160152616-A1 NOVEL TRICYCLIC COMPOUNDS AND PROCESS FOR PREPARATION THEREOF CCKAR, HKDC1, NRDC PARP1 731/4885TP53 3481/4885
US-11002524-B2 Cyclic compounds and process for the preparation thereof VIP, TREH, CCKAR PARP1 1835/4885TP53 4455/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.