Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | ACE | P12821 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.40 |
| ▸ | KLK7 | P49862 | 1/20 | 0.40 |
| ▸ | CCKBR | P32239 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7308940 | 0.84 | ACE (0.45) | MAPTMAPK1POLBACE | |
| SCHEMBL7304574 | 0.83 | MAPT (0.52) | MAPTMAPK1POLBACEKDM4E | |
| SCHEMBL7299518 | 0.80 | ACE (0.44) | MAPTMAPK1POLBACE | |
| SCHEMBL7309615 | 0.78 | MAPT (0.56) | MAPTMAPK1POLBACETDP1 | |
| SCHEMBL7305875 | 0.78 | ACE (0.49) | MAPTMAPK1POLBACE | |
| SCHEMBL7294995 | 0.77 | CTSS (0.56) | ACEKLK5KLK7 | |
| SCHEMBL7331480 | 0.76 | ITGB3 (0.42) | MAPTKMT2A | |
| SCHEMBL7296817 | 0.75 | MAPT (0.44) | MAPTPOLBACETDP1KLK5 | |
| Iodide SCHEMBL9221941 | 0.74 | CCKBR (0.43) | MAPTPOLBACETDP1KLK5 | |
| SCHEMBL9217707 | 0.73 | SYK (0.46) | MAPTMAPK1POLBACEKLK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5430024-A | Peptides bearing N-terminal amidino moieties and their use as inhibitors of platelet aggregation | HOFFMANN-LA ROCHE INC. (US) | 1995-07-04 | — | — | US | disclosed |
| US-5273982-A | An amidinoaryleneamidoalkylpiperazinyleneacetic acid | HOFFMANN-LA ROCHE INC. (US) | 1993-12-28 | — | — | US | disclosed |