Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | ACE | P12821 | 2/20 | 0.50 |
| ▸ | CCKBR | P32239 | 1/20 | 0.50 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.49 |
| ▸ | KLK7 | P49862 | 1/20 | 0.47 |
| ▸ | CTSS | P25774 | 2/20 | 0.47 |
| ▸ | CTSL | P07711 | 1/20 | 0.47 |
| ▸ | CTSB | P07858 | 1/20 | 0.47 |
| ▸ | CTSK | P43235 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | SYK | P43405 | 1/20 | 0.46 |
| ▸ | REN | P00797 | 4/20 | 0.45 |
| ▸ | AKT1 | P31749 | 1/20 | 0.44 |
| ▸ | MMP9 | P14780 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7309615 | 0.94 | MAPT (0.56) | MAPTPOLBMAPK1ACECCKBR | |
| SCHEMBL9217707 | 0.88 | SYK (0.46) | MAPTPOLBMAPK1ACECCKBR | |
| SCHEMBL7294995 | 0.88 | CTSS (0.56) | ACEKLK5KLK7CTSSCTSL | |
| SCHEMBL9220679 | 0.87 | MAPT (0.61) | MAPTPOLBMAPK1KLK5KLK7 | |
| SCHEMBL7304807 | 0.85 | MEN1 (0.48) | MAPTPOLBKLK5KLK7CTSS | |
| SCHEMBL9220259 | 0.85 | REN (0.55) | KLK5KLK7CTSSCTSLCTSB | |
| SCHEMBL7336100 | 0.84 | CTSL (0.49) | MAPTACECCKBRKLK5KLK7 | |
| SCHEMBL27510152 | 0.84 | CTSS (0.53) | ACEKLK5KLK7CTSSCTSL | |
| SCHEMBL7438212 | 0.84 | MAPT (0.65) | MAPTPOLBMAPK1ACEKLK5 | |
| SCHEMBL9215449 | 0.83 | MAPT (0.45) | MAPTPOLBMAPK1ACECCKBR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0445796-B1 | Derivatives of acetic acid containing peptide bonds | HOFFMANN LA ROCHE (CH) | 1998-06-17 | — | — | EP | disclosed |
| US-5430024-A | Peptides bearing N-terminal amidino moieties and their use as inhibitors of platelet aggregation | HOFFMANN-LA ROCHE INC. (US) | 1995-07-04 | — | — | US | disclosed |
| US-5273982-A | An amidinoaryleneamidoalkylpiperazinyleneacetic acid | HOFFMANN-LA ROCHE INC. (US) | 1993-12-28 | — | — | US | disclosed |
| EP-0445796-A2 | Derivatives of acetic acid | F. HOFFMANN-LA ROCHE AG (CH) | 1991-09-11 | — | — | EP | disclosed |