Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 6/20 | 0.58 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.55 |
| ▸ | METAP1 | P53582 | 2/20 | 0.49 |
| ▸ | METAP2 | P50579 | 1/20 | 0.49 |
| ▸ | PDE5A | O76074 | 5/20 | 0.47 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | NOS1 | P29475 | 1/20 | 0.43 |
| ▸ | NOS2 | P35228 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL805045 | 0.79 | NUDT1 (0.60) | AURKANUDT1METAP1METAP2PDE5A | |
| SCHEMBL16105055 | 0.74 | AURKA (0.45) | AURKANUDT1METAP1METAP2PDE5A | |
| SCHEMBL1170747 | 0.74 | METAP1 (0.72) | AURKANUDT1METAP1METAP2PDE5A | |
| SCHEMBL3936352 | 0.74 | AURKA (0.50) | AURKANUDT1METAP1METAP2PDE5A | |
| Hydrochloric Acid SCHEMBL9396770 | 0.73 | AURKA (0.49) | AURKANUDT1METAP1METAP2PDE5A | |
| SCHEMBL31490802 | 0.72 | NUDT1 (0.62) | AURKANUDT1METAP1METAP2PDE5A | |
| SCHEMBL239645 | 0.72 | NUDT1 (0.62) | AURKANUDT1METAP1METAP2PDE5A | |
| SCHEMBL3960231 | 0.71 | CYP2C9 (0.57) | AURKANUDT1METAP1METAP2PDE5A | |
| SCHEMBL17967942 | 0.71 | KMT2A (0.47) | PDE5ANPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL358399 | 0.71 | LMNA (0.62) | NUDT1HPGDNPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0670838-A1 | SUBSTITUTED-PHENYL(N,N'-CYCLOALKYL/ALKYL CARBOXAMIDE)-1H/3H-IMIDAZO 4,5-b]PYRIDINE COMPOUNDS AS PAF ANTAGONISTS | G.D. SEARLE & CO. (US) | 1995-09-13 | — | — | EP | disclosed |
| US-5359073-A | Substituted-phenyl (N,N'-cycloalkyl/alkyl carboxamide)-1H/3H-imidazo[4,5-b]pyridine compounds as PAF antagonists | G. D. SEARLE & CO. (US) | 1994-10-25 | — | — | US | disclosed |