Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 7/20 | 0.38 |
| ▸ | RAB9A | P51151 | 7/20 | 0.38 |
| ▸ | MEN1 | O00255 | 6/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.38 |
| ▸ | LCK | P06239 | 2/20 | 0.37 |
| ▸ | HCK | P08631 | 2/20 | 0.37 |
| ▸ | SRC | P12931 | 2/20 | 0.37 |
| ▸ | KDR | P35968 | 2/20 | 0.37 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.35 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | CDK9 | P50750 | 1/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9215802 | 0.84 | RAB9A (0.38) | SMN1; SMN2ALDH1A1NPC1RAB9AMEN1 | |
| SCHEMBL9221803 | 0.83 | ALDH1A1 (0.44) | SMN1; SMN2ALDH1A1NPC1RAB9AMEN1 | |
| SCHEMBL9218534 | 0.82 | SRC (0.47) | SMN1; SMN2ALDH1A1NPC1RAB9AMEN1 | |
| SCHEMBL9220203 | 0.82 | RAB9A (0.34) | SMN1; SMN2ALDH1A1NPC1RAB9AMEN1 | |
| SCHEMBL9219234 | 0.80 | NPC1 (0.57) | NPC1RAB9AMEN1KMT2ASRC | |
| SCHEMBL9212913 | 0.80 | EGLN2 (0.43) | SMN1; SMN2ALDH1A1NPC1RAB9AMEN1 | |
| SCHEMBL9214289 | 0.80 | KDR (0.50) | ALDH1A1SRCKDRDYRK1AMAPT | |
| SCHEMBL9172768 | 0.79 | RAB9A (0.55) | SMN1; SMN2ALDH1A1NPC1RAB9AMEN1 | |
| SCHEMBL9221091 | 0.79 | PIK3CD (0.30) | HCKSRCKDR | |
| SCHEMBL9210159 | 0.79 | RAB9A (0.34) | SMN1; SMN2ALDH1A1NPC1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0269859-B2 | Pyrazolotriazine compounds | OTSUKA PHARMA CO LTD (JP) | 1995-10-18 | — | — | EP | disclosed |
| US-4824834-A | TREATING GOUT | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1989-04-25 | — | — | US | disclosed |
| EP-0269859-A2 | Pyrazolotriazine compounds | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1988-06-08 | — | — | EP | disclosed |