Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 4/20 | 0.57 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.57 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.57 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HRH2 | P25021 | 2/20 | 0.46 |
| ▸ | HRH1 | P35367 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | MMP1 | P03956 | 1/20 | 0.46 |
| ▸ | MMP9 | P14780 | 1/20 | 0.46 |
| ▸ | MMP13 | P45452 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9208504 | 0.94 | HRH2 (0.49) | CHRNB2CHRNA4CHRNB4CHRNA3POLB | |
| SCHEMBL9739220 | 0.92 | HRH3 (0.52) | CHRNB2CHRNA4CHRNB4CHRNA3POLB | |
| SCHEMBL9740303 | 0.91 | HRH3 (0.60) | CHRNB2CHRNA4CHRNB4CHRNA3MAPT | |
| SCHEMBL9205156 | 0.87 | CHRNB2 (0.54) | CHRNB2CHRNA4CHRNB4CHRNA3POLB | |
| SCHEMBL9211609 | 0.86 | KDM4E (0.55) | CHRNB2CHRNA4CHRNB4CHRNA3HRH3 | |
| SCHEMBL9205099 | 0.85 | HRH3 (0.48) | CHRNB2CHRNA4CHRNB4CHRNA3HRH3 | |
| SCHEMBL9740178 | 0.83 | HRH3 (0.48) | POLBMAPTHRH3KMT2AALDH1A1 | |
| SCHEMBL9739559 | 0.80 | POLB (0.46) | POLBMAPTHRH3ALDH1A1HRH2 | |
| SCHEMBL9208592 | 0.80 | HTR1A (0.50) | — | |
| SCHEMBL9210505 | 0.79 | HRH3 (0.57) | CHRNB2CHRNA4CHRNB4CHRNA3HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5175157-A | Cardiovascular disorders | BOEHRINGER INGELHEIM GMBH (DE) | 1992-12-29 | — | — | US | disclosed |