Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.69 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.69 |
| ▸ | LMNA | P02545 | 2/20 | 0.69 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.69 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.69 |
| ▸ | RAB9A | P51151 | 1/20 | 0.69 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.67 |
| ▸ | HPGD | P15428 | 1/20 | 0.67 |
| ▸ | MAPT | P10636 | 3/20 | 0.60 |
| ▸ | GSK3B | P49841 | 2/20 | 0.60 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.60 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.56 |
| ▸ | FEN1 | P39748 | 1/20 | 0.56 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10563005 | 0.89 | SMN1; SMN2 (0.65) | SMN1; SMN2HIF1ALMNAFFAR1CYP1A2 | |
| SCHEMBL116339 | 0.87 | MAPK1 (0.67) | SMN1; SMN2HIF1ALMNARAB9AL3MBTL1 | |
| SCHEMBL6610437 | 0.87 | HDAC1 (0.64) | SMN1; SMN2HIF1ALMNAFFAR1CYP1A2 | |
| SCHEMBL8534233 | 0.85 | SMN1; SMN2 (0.84) | SMN1; SMN2HIF1ALMNAFFAR1CYP1A2 | |
| SCHEMBL10972806 | 0.84 | GSK3B (0.61) | SMN1; SMN2HIF1ALMNAFFAR1CYP1A2 | |
| SCHEMBL3791851 | 0.83 | ALDH1A1 (0.75) | SMN1; SMN2HIF1ALMNAFFAR1CYP1A2 | |
| Ethylene SCHEMBL11817466 | 0.83 | MAPK1 (0.61) | SMN1; SMN2HIF1ALMNAFFAR1CYP1A2 | |
| SCHEMBL11489631 | 0.82 | RAB9A (0.62) | SMN1; SMN2HIF1ALMNAFFAR1CYP1A2 | |
| Fenbufen SCHEMBL25117 | 0.82 | SMN1; SMN2 (1.00) | SMN1; SMN2HIF1ALMNAFFAR1CYP1A2 | |
| Fenbufen SCHEMBL11329267 | 0.82 | SMN1; SMN2 (1.00) | SMN1; SMN2HIF1ALMNAFFAR1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1995003291-A1 | NOVEL SUBSTITUTED 1-PROPENE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESS FOR PREPARING SAME | Richter Gedeon Vegyészeti Gyár Rt. (HU) | 1995-02-02 | — | — | WO | disclosed |
| US-4275071-A | Imidazole derivatives | RECORDATI S.A. (CH) | 1981-06-23 | — | — | US | disclosed |
| US-4239759-A | Morpholino containing compounds, compositions and use thereof | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1980-12-16 | — | — | US | disclosed |
| US-4110447-A | Anti-inflammatory (halo-4-biphenylyl)-alkanolamines | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 1978-08-29 | — | — | US | disclosed |