SCHEMBL9218476

SCHEMBL9218476

O=C(O)C1CCC(c2ccccn2)=N1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 4/20 0.41
KDM6B O15054 1/20 0.41
KDM4A O75164 1/20 0.41
KDM5C P41229 1/20 0.41
KDM4C Q9H3R0 1/20 0.41
KDM2A Q9Y2K7 1/20 0.41
KDM3A Q9Y4C1 1/20 0.41
LMNA P02545 4/20 0.41
P4HTM Q9NXG6 3/20 0.41
CYP1A2 P05177 1/20 0.41
POLB P06746 1/20 0.41
CCR1 P32246 1/20 0.41
CCR5 P51681 1/20 0.41
CCR8 P51685 1/20 0.41
METAP1 P53582 1/20 0.41
BLM P54132 1/20 0.41
HIF1A Q16665 1/20 0.41
DOHH Q9BU89 1/20 0.41
RAB9A P51151 2/20 0.39
SMN1; SMN2 Q16637 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29442058 1.00 KDM4E (0.41) KDM4EKDM6BKDM4AKDM5CKDM4C
SCHEMBL2041199 0.82 RAB9A (0.39) KDM4ELMNAP4HTMCYP1A2POLB
SCHEMBL14328250 0.80 RAB9A (0.39) LMNARAB9ASMN1; SMN2NPC1KMT2A
SCHEMBL9542642 0.80 RAB9A (0.39) LMNARAB9ASMN1; SMN2NPC1KMT2A
SCHEMBL15536916 0.77 ALOX5 (0.32) ALDH1A1
SCHEMBL11368798 0.74 HTR2B (0.42) RAB9ASMN1; SMN2NPC1KMT2AALDH1A1
SCHEMBL3827477 0.73 NAPRT (0.39) LMNAL3MBTL1NAPRTALDH1A1
SCHEMBL3832352 0.73 NAPRT (0.39) LMNAL3MBTL1NAPRTALDH1A1
SCHEMBL28788872 0.73 KIF11 (0.43) KDM4EPOLBRAB9ANPC1KMT2A
SCHEMBL28788871 0.73 KIF11 (0.43) KDM4EPOLBRAB9ANPC1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-7118264-A None JP disclosed
US-11421223-B2 Processes and host cells for genome, pathway, and biomolecular engineering ENEVOLV, INC. (US) 2022-08-23 US disclosed
US-20190309289-A1 PROCESSES AND HOST CELLS FOR GENOME, PATHWAY, AND BIOMOLECULAR ENGINEERING ENEVOLV, INC. 2019-10-10 US disclosed
US-10370654-B2 Processes and host cells for genome, pathway, and biomolecular engineering ENEVOLV, INC. (US) 2019-08-06 US disclosed
US-20180320170-A1 PROCESSES AND HOST CELLS FOR GENOME, PATHWAY, AND BIOMOLECULAR ENGINEERING ENEVOLV, INC. 2018-11-08 US disclosed
US-9944925-B2 Processes and host cells for genome, pathway, and biomolecular engineering ENEVOLV, INC. 2018-04-17 US disclosed
US-20160186168-A1 PROCESSES AND HOST CELLS FOR GENOME, PATHWAY, AND BIOMOLECULAR ENGINEERING ENEVOLV, INC. 2016-06-30 US disclosed
EP-3027754-A1 PROCESSES AND HOST CELLS FOR GENOME, PATHWAY, AND BIOMOLECULAR ENGINEERING enEvolv, Inc. (US) 2016-06-08 EP disclosed
WO-2015017866-A1 PROCESSES AND HOST CELLS FOR GENOME, PATHWAY, AND BIOMOLECULAR ENGINEERING ENEVOLV, INC. (US) 2015-02-05 WO disclosed
JP-H07118264-A METAL COMPLEX OF PYRROLINECARBOXYLIC ACID DERIVATIVE AND ITS USE KIMURA YUKIO 1995-05-09 JP disclosed