Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | PRMT1 | Q99873 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.41 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9213741 | 0.99 | ALDH1A1 (0.53) | ALDH1A1TDP1KDM4ECYP1A2CYP3A4 | |
| SCHEMBL9214593 | 0.95 | ALDH1A1 (0.58) | ALDH1A1TDP1KDM4ECYP1A2CYP3A4 | |
| SCHEMBL3489743 | 0.90 | L3MBTL1 (0.53) | ALDH1A1TP53GAAL3MBTL1PRMT1 | |
| SCHEMBL9220298 | 0.87 | ALDH1A1 (0.44) | ALDH1A1TDP1KDM4ECYP1A2CYP3A4 | |
| SCHEMBL9220257 | 0.86 | ALDH1A1 (0.42) | ALDH1A1TDP1KDM4ECYP1A2CYP3A4 | |
| SCHEMBL9215811 | 0.82 | NR3C1 (0.44) | ALDH1A1TDP1KDM4ECYP1A2CYP3A4 | |
| SCHEMBL3491178 | 0.82 | LMNA (0.52) | ALDH1A1CYP1A2CYP3A4TP53MEN1 | |
| SCHEMBL3489059 | 0.81 | CYP3A4 (0.47) | TDP1CYP1A2CYP3A4MAPK1CYP2C19 | |
| SCHEMBL3490267 | 0.81 | CYP3A4 (0.47) | TDP1CYP1A2CYP3A4MAPK1CYP2C19 | |
| SCHEMBL3639244 | 0.80 | NR3C1 (0.47) | ALDH1A1TDP1KDM4ECYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0636124-A1 | 3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE-1,1-DIOXIDE-3-CARBOXYLIC ACID DERIVATIVES, PREPARATION THEREOF AND DRUGS CONTAINING SAME | Aventis Pharma S.A. (FR) | 1995-02-01 | — | — | EP | disclosed |
| WO-1993021170-A1 | 3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE-1,1-DIOXIDE-3-CARBOXYLIC ACID DERIVATIVES, PREPARATION THEREOF AND DRUGS CONTAINING SAME | RHONE-POULENC RORER S.A. (FR) | 1993-10-28 | — | — | WO | disclosed |