Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAAA | Q02083 | 2/20 | 0.50 |
| ▸ | DRD2 | P14416 | 2/20 | 0.47 |
| ▸ | DRD4 | P21917 | 2/20 | 0.47 |
| ▸ | DRD3 | P35462 | 2/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.46 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.46 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.46 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | ASAH1 | Q13510 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9212461 | 0.84 | NAAA (0.55) | NAAAALDH1A1HTTKDM4EGLA | |
| SCHEMBL9216814 | 0.80 | NAAA (0.50) | NAAADRD2DRD4DRD3ALOX15 | |
| SCHEMBL9219330 | 0.77 | NAAA (0.50) | NAAADRD2DRD4DRD3ALOX15 | |
| SCHEMBL9211979 | 0.77 | ALDH1A1 (0.43) | NAAAALDH1A1HTTKDM4EGLA | |
| SCHEMBL9216809 | 0.76 | NAAA (0.49) | NAAADRD2DRD4DRD3ALOX15 | |
| SCHEMBL9219281 | 0.76 | HDAC1 (0.57) | NAAADRD2DRD4DRD3ALOX15 | |
| SCHEMBL9220536 | 0.74 | HDAC1 (0.58) | NAAADRD2DRD4DRD3ALOX15 | |
| SCHEMBL11438908 | 0.74 | GRIN2D (0.47) | ESR2 | |
| SCHEMBL1004988 | 0.73 | DRD2 (0.81) | NAAADRD2DRD4DRD3POLB | |
| SCHEMBL9212475 | 0.72 | NAAA (0.56) | NAAADRD2DRD4DRD3ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0512570-B1 | Urea derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1995-10-11 | — | — | EP | disclosed |
| CN-1067886-A | New urea derivatives, their preparation method and pharmaceutical composition thereof | FUJISAWA PHARMACEUTICAL CO (JP) | 1993-01-13 | — | — | CN | disclosed |
| EP-0512570-A1 | Urea derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-11-11 | — | — | EP | disclosed |