SCHEMBL9219657

SCHEMBL9219657

Cc1ccc2oc(CN(Cc3ccc(Cl)c(Cl)c3)C(=O)Nc3c(F)cc(F)cc3F)c(-c3ccc(Cl)cc3)c2c1

nearest known ligand 0.36

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 1/20 0.36
CENPE Q02224 5/20 0.36
MAPT P10636 4/20 0.34
TP53 P04637 2/20 0.34
THRB P10828 1/20 0.34
CSNK2A2 P19784 1/20 0.34
CSNK2B P67870 1/20 0.34
CSNK2A1 P68400 1/20 0.34
PTPN1 P18031 1/20 0.34
MEN1 O00255 2/20 0.33
KMT2A Q03164 2/20 0.33
EGFR P00533 1/20 0.33
ERBB2 P04626 1/20 0.33
PPARG P37231 1/20 0.33
PPARA Q07869 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9213879 0.94 L3MBTL1 (0.39) L3MBTL1MAPTTP53THRBCSNK2A2
SCHEMBL9218677 0.93 L3MBTL1 (0.39) L3MBTL1MAPTTP53THRBCSNK2A2
SCHEMBL9215732 0.93 EGFR (0.38) L3MBTL1MAPTTP53THRBCSNK2A2
SCHEMBL9217824 0.91 L3MBTL1 (0.37) L3MBTL1MAPTTP53THRBCSNK2A2
SCHEMBL9221161 0.90 L3MBTL1 (0.38) L3MBTL1MAPTTP53THRBCSNK2A2
SCHEMBL5500482 0.90 MEN1 (0.44) L3MBTL1MAPTTP53THRBCSNK2A2
SCHEMBL9218562 0.89 MAPT (0.41) L3MBTL1MAPTTP53THRBCSNK2A2
SCHEMBL9681518 0.89 NPC1 (0.39) L3MBTL1MAPTTP53THRBCSNK2A2
SCHEMBL9220046 0.88 L3MBTL1 (0.36) L3MBTL1MAPTTP53THRBCSNK2A2
SCHEMBL9683150 0.87 HTT (0.47) L3MBTL1MAPTTP53THRBMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0512570-B1 Urea derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same FUJISAWA PHARMACEUTICAL CO (JP) 1995-10-11 EP disclosed
EP-0512570-A1 Urea derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1992-11-11 EP disclosed