SCHEMBL9220580

SCHEMBL9220580

Clc1ccc(-c2nn[c]s2)c(Cl)c1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 5/20 0.51
ALDH1A1 P00352 3/20 0.51
KDM4E B2RXH2 3/20 0.51
GAA P10253 2/20 0.51
MGAM O43451 1/20 0.51
SI P14410 1/20 0.51
MGAM2 Q2M2H8 1/20 0.51
HSD11B1 P28845 3/20 0.43
AHR P35869 1/20 0.40
NPC1 O15118 4/20 0.38
SMN1; SMN2 Q16637 3/20 0.38
HPGD P15428 2/20 0.38
TP53 P04637 2/20 0.38
TSHR P16473 1/20 0.38
NPSR1 Q6W5P4 1/20 0.38
HSD17B10 Q99714 1/20 0.38
PRKD3 O94806 1/20 0.38
PRKCG P05129 1/20 0.38
PRKCB P05771 1/20 0.38
IL1R1 P14778 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2428375 0.73 KDM4E (0.46) RAB9AALDH1A1KDM4EGAAMGAM
SCHEMBL2089754 0.71 RAB9A (0.47) RAB9AALDH1A1KDM4EGAAMGAM
SCHEMBL1893056 0.71 KMT2A (0.43) RAB9ANPC1SMN1; SMN2TP53TSHR
SCHEMBL31286639 0.69 RAB9A (0.53) RAB9AALDH1A1KDM4EGAAMGAM
SCHEMBL464507 0.68 AHR (0.64) RAB9AALDH1A1KDM4EGAAMGAM
SCHEMBL29624840 0.68 AHR (0.64) RAB9AALDH1A1KDM4EGAAMGAM
SCHEMBL8045944 0.68 ALDH1A1 (0.65) RAB9AALDH1A1KDM4EGAAMGAM
SCHEMBL22816357 0.68 KDM4E (0.47) RAB9AALDH1A1KDM4EGAAMGAM
SCHEMBL22816341 0.68 SHMT1 (0.49) RAB9AALDH1A1KDM4EGAAMGAM
SCHEMBL3434993 0.68 ALDH1A1 (1.00) RAB9AALDH1A1KDM4EGAAMGAM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0478974-B1 N-Heteroaryl-2-nitroanilines BASF AG (DE) 1995-12-27 EP disclosed
US-5298515-A N-hetaryl-2-nitroanilines BASF AKTIENGESELLSCHAFT (DE) 1994-03-29 US disclosed
EP-0478974-A1 N-Heteroaryl-2-nitroanilines BASF Aktiengesellschaft (DE) 1992-04-08 EP disclosed