Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 5/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | MET | P08581 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.35 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9312321 | 0.89 | MAPT (0.42) | MAPTCA2THRBUSP2NR4A2 | |
| SCHEMBL9212750 | 0.88 | MAPT (0.41) | MAPTCA2THRBUSP2NR4A2 | |
| SCHEMBL9220714 | 0.86 | MTNR1A (0.47) | MAPTNR4A2ALDH1A1NPC1RAB9A | |
| SCHEMBL9211264 | 0.85 | ALDH1A1 (0.34) | MAPTPOLBCHEK1METGSK3B | |
| SCHEMBL23987343 | 0.83 | NR4A2 (0.40) | MAPTNR4A2POLBALDH1A1MEN1 | |
| SCHEMBL9209687 | 0.83 | TBXAS1 (0.36) | MAPTTP53CHEK1METGSK3B | |
| SCHEMBL9219061 | 0.82 | MAPT (0.43) | MAPTTP53ALDH1A1RECQLNPC1 | |
| SCHEMBL9218225 | 0.81 | ALDH1A1 (0.37) | MAPTPOLBALDH1A1NPC1RAB9A | |
| SCHEMBL9312295 | 0.80 | TBXAS1 (0.34) | MAPTMEN1KMT2A | |
| SCHEMBL9215423 | 0.79 | PTK2 (0.36) | MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0433233-B1 | Heterocyclic compounds | CIBA GEIGY AG (CH) | 1995-01-25 | — | — | EP | disclosed |
| US-5376677-A | Fungicides | CIBA-GEIGY CORPORATION (US) | 1994-12-27 | — | — | US | disclosed |
| EP-0433233-A1 | Heterocyclic compounds | CIBA-GEIGY AG (CH) | 1991-06-19 | — | — | EP | disclosed |