Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 11/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 8/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9214375 | 0.86 | OPRM1 (0.48) | OPRM1SLC6A4SLC6A2OPRK1OPRD1 | |
| SCHEMBL9227964 | 0.76 | OPRM1 (0.46) | OPRM1SLC6A4SLC6A2OPRK1OPRD1 | |
| SCHEMBL9228922 | 0.76 | OPRM1 (0.46) | OPRM1SLC6A4SLC6A2OPRK1OPRD1 | |
| SCHEMBL9224261 | 0.70 | NPY1R (0.39) | OPRM1SLC6A4SLC6A2OPRK1OPRD1 | |
| SCHEMBL9218075 | 0.69 | OPRM1 (0.49) | OPRM1SLC6A4SLC6A2OPRK1OPRD1 | |
| SCHEMBL9223138 | 0.69 | ALOX5 (0.66) | — | |
| SCHEMBL9250652 | 0.68 | OPRM1 (0.44) | OPRM1SLC6A4SLC6A2OPRK1OPRD1 | |
| SCHEMBL1599480 | 0.67 | ALOX5 (0.54) | OPRD1 | |
| SCHEMBL9279813 | 0.67 | ALOX5 (0.41) | OPRM1SLC6A4SLC6A2 | |
| SCHEMBL22781500 | 0.66 | OPRM1 (0.52) | OPRM1SLC6A4SLC6A2OPRK1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5403859-A | PHENYLENE-CYCLIC ETHER COMPOUNDS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1995-04-04 | — | — | US | disclosed |
| EP-0375404-B1 | Heterocyclic derivatives | ICI PLC (GB) | 1994-02-09 | — | — | EP | disclosed |
| US-5234950-A | Antiallergens, antiinflammatory agents; cardiovascular disorders, antiarthritic | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-08-10 | — | — | US | disclosed |
| US-5098930-A | Inhibitors of lipoxygenase for treatment of diseases mediated with leukotrienes | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-03-24 | — | — | US | disclosed |
| EP-0375404-A2 | Heterocyclic derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1990-06-27 | — | — | EP | disclosed |