Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 4/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 5/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.41 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1599480 | 0.84 | ALOX5 (0.54) | ALOX5OPRD1 | |
| SCHEMBL9226853 | 0.81 | OPRM1 (0.42) | OPRM1SLC6A4SLC6A2OPRD1OPRK1 | |
| SCHEMBL9248765 | 0.79 | ALOX5 (0.49) | ALOX5 | |
| SCHEMBL9259587 | 0.79 | ALOX5 (0.56) | OPRM1SLC6A4SLC6A2ALOX5OPRD1 | |
| SCHEMBL7532983 | 0.78 | ACHE (0.55) | OPRM1SLC6A4ALOX5OPRD1SLC22A1 | |
| SCHEMBL9222785 | 0.76 | ALOX5 (0.40) | ALOX5 | |
| SCHEMBL9136332 | 0.76 | ALOX5 (0.54) | OPRM1SLC6A4ALOX5OPRD1SLC22A1 | |
| SCHEMBL9138011 | 0.76 | OPRD1 (0.63) | OPRM1ALOX5OPRD1OPRK1 | |
| SCHEMBL9222022 | 0.75 | ALOX5 (0.80) | ALOX5 | |
| SCHEMBL3565566 | 0.75 | OPRM1 (0.38) | OPRM1ALOX5OPRD1OPRK1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5401751-A | Enzyme inhibitors for 5-lipoxygenase | ZENECA LIMITED (GB) | 1995-03-28 | — | — | US | disclosed |
| US-5236919-A | Inhibitorsof enzyme 5-lipoxygenase | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-08-17 | — | — | US | disclosed |
| US-5134148-A | Heterocycles for use as inhibitors of leukotrienes | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-07-28 | — | — | US | disclosed |
| EP-0385662-A2 | Heterocycles with inhibitory activity of 5-lipoxygenase | ZENECA LIMITED (GB) | 1990-09-05 | — | — | EP | disclosed |