Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK7 | P49862 | 1/20 | 0.45 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 3/20 | 0.44 |
| ▸ | SYK | P43405 | 1/20 | 0.43 |
| ▸ | CA5A | P35218 | 2/20 | 0.43 |
| ▸ | CTSK | P43235 | 2/20 | 0.43 |
| ▸ | CTSS | P25774 | 2/20 | 0.43 |
| ▸ | MMP8 | P22894 | 1/20 | 0.43 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.42 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.42 |
| ▸ | PSMB9 | P28065 | 1/20 | 0.42 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 3/20 | 0.42 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.41 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.41 |
| ▸ | ACE | P12821 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9224778 | 0.87 | PSMB5 (0.51) | KLK7KLK5CA2CA5ACTSK | |
| SCHEMBL9214875 | 0.85 | CTSS (0.51) | KLK7KLK5CA2SYKCA5A | |
| SCHEMBL7331480 | 0.83 | ITGB3 (0.42) | SMN1; SMN2CA2CTSKCTSSITGB3 | |
| SCHEMBL9223556 | 0.82 | SMN1; SMN2 (0.43) | SMN1; SMN2CA2CA5AMMP8CA1 | |
| SCHEMBL7304574 | 0.82 | MAPT (0.52) | KLK7KLK5SYKCTSKCTSS | |
| SCHEMBL9217707 | 0.80 | SYK (0.46) | KLK7KLK5SYKCTSKCTSS | |
| SCHEMBL7404441 | 0.80 | KLK7 (0.51) | KLK7KLK5CA2CA5ACTSK | |
| SCHEMBL9217103 | 0.79 | SYK (0.53) | KLK7KLK5SYKCTSSACE | |
| SCHEMBL7295520 | 0.79 | SYK (0.53) | KLK7KLK5SYKCTSSACE | |
| SCHEMBL7304807 | 0.79 | MEN1 (0.48) | KLK7KLK5CTSKCTSSPSMB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5430024-A | Peptides bearing N-terminal amidino moieties and their use as inhibitors of platelet aggregation | HOFFMANN-LA ROCHE INC. (US) | 1995-07-04 | — | — | US | disclosed |
| US-5273982-A | An amidinoaryleneamidoalkylpiperazinyleneacetic acid | HOFFMANN-LA ROCHE INC. (US) | 1993-12-28 | — | — | US | disclosed |