SCHEMBL9227158

SCHEMBL9227158

Cc1cc(Cl)ccc1[S+]([O-])c1ccc(Cl)cc1C

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 1/20 0.41
NOX1 Q9Y5S8 1/20 0.40
CYP2A6 P11509 1/20 0.35
POLB P06746 2/20 0.34
ALDH1A1 P00352 1/20 0.34
GAA P10253 1/20 0.34
NOTUM Q6P988 1/20 0.34
FLT1 P17948 1/20 0.34
FLT4 P35916 1/20 0.34
KDR P35968 1/20 0.34
TP53 P04637 2/20 0.33
SMN1; SMN2 Q16637 2/20 0.33
RAPGEF4 Q8WZA2 2/20 0.33
NPC1 O15118 1/20 0.33
RAB9A P51151 1/20 0.33
LMNA P02545 1/20 0.33
TSHR P16473 1/20 0.33
HTR2A P28223 1/20 0.33
HTR2C P28335 1/20 0.33
HTR2B P41595 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30899314 0.76 TDP1 (0.42) CYP3A4CYP2A6ALDH1A1TP53SMN1; SMN2
SCHEMBL3164872 0.76 TP53 (0.48) CYP3A4CYP2A6ALDH1A1TP53SMN1; SMN2
SCHEMBL360036 0.76 TDP1 (0.42) CYP3A4CYP2A6ALDH1A1TP53SMN1; SMN2
SCHEMBL11148880 0.74 ALDH1A1 (0.36) CYP2A6ALDH1A1FLT1FLT4KDR
SCHEMBL10539448 0.73 IDO1 (0.35) CYP3A4CYP2A6ALDH1A1TP53SMN1; SMN2
SCHEMBL4131313 0.73 ACHE (0.35) CYP2A6POLBALDH1A1SMN1; SMN2LMNA
SCHEMBL10539835 0.73 HSD17B10 (0.50) CYP3A4ALDH1A1TP53SMN1; SMN2LMNA
SCHEMBL6938683 0.73 ALOX15 (0.41) CYP3A4ALDH1A1LMNATSHRHTR2B
SCHEMBL9629038 0.73 ALDH1A1 (0.52) CYP3A4POLBALDH1A1GAATP53
SCHEMBL16269520 0.72 RAB9A (0.36) CYP3A4CYP2A6TP53SMN1; SMN2RAPGEF4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5409893-A Administering with platinum complexes BOEHRINGER MANNHEIM ITALIA, S.P.A. (IT) 1995-04-25 US disclosed
EP-0471709-B1 RUTHENIUM(III) COMPLEXES AS ANTINEOPLASTIC AGENTS BOEHRINGER MANNHEIM ITALIA (IT) 1994-11-30 EP disclosed
US-5144004-A Heat resistance, selective degradation, reaction of halogen substituted sulfones and sulfoxides and alkali metal sulfides PHILLIPS PETROLEUM COMPANY (US) 1992-09-01 US disclosed
EP-0471709-A1 RUTHENIUM(III) COMPLEXES AS ANTINEOPLASTIC AGENTS. BOEHRINGER MANNHEIM ITALIA (IT) 1992-02-26 EP disclosed
WO-1990013553-A1 RUTHENIUM(III) COMPLEXES AS ANTINEOPLASTIC AGENTS BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) 1990-11-15 WO disclosed