Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.59 |
| ▸ | NOS1 | P29475 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | TSHR | P16473 | 3/20 | 0.51 |
| ▸ | NOS2 | P35228 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | APEX1 | P27695 | 1/20 | 0.51 |
| ▸ | NOS3 | P29474 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | BLM | P54132 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29674805 | 0.79 | ALDH1A1 (0.61) | ALDH1A1TDP1NOS1SMN1; SMN2TSHR | |
| SCHEMBL1010663 | 0.79 | ALDH1A1 (0.61) | ALDH1A1TDP1NOS1SMN1; SMN2TSHR | |
| Methane SCHEMBL27506999 | 0.78 | ALDH1A1 (0.59) | ALDH1A1TDP1NOS1SMN1; SMN2TSHR | |
| SCHEMBL27415737 | 0.78 | ALDH1A1 (0.59) | ALDH1A1TDP1NOS1SMN1; SMN2TSHR | |
| Bromide SCHEMBL11820178 | 0.78 | ALDH1A1 (0.59) | ALDH1A1TDP1NOS1SMN1; SMN2TSHR | |
| SCHEMBL3292426 | 0.77 | ALDH1A1 (0.63) | ALDH1A1TDP1NOS1SMN1; SMN2TSHR | |
| SCHEMBL57184 | 0.77 | ALDH1A1 (1.00) | ALDH1A1TDP1SMN1; SMN2TSHRCYP3A4 | |
| SCHEMBL9735773 | 0.77 | ALDH1A1 (0.69) | ALDH1A1TDP1NOS1SMN1; SMN2TSHR | |
| SCHEMBL29378762 | 0.77 | ALDH1A1 (1.00) | ALDH1A1TDP1SMN1; SMN2TSHRCYP3A4 | |
| SCHEMBL27780773 | 0.77 | ALDH1A1 (1.00) | ALDH1A1TDP1SMN1; SMN2TSHRCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180148437-A1 | Novel Ezrin Inhibitors and Methods of Making and Using | UNITED STATES GOVERNMENT | 2018-05-31 | — | — | US | disclosed |
| US-9522908-B2 | Ezrin inhibitors and methods of making and using | Gerogetown University (US) | 2016-12-20 | — | — | US | disclosed |
| US-9522908-B2 | Ezrin inhibitors and methods of making and using | Gerogetown University (US) | 2016-12-20 | — | — | US | disclosed |
| US-20140135325-A1 | NOVEL EZRIN INHIBITORS AND METHODS OF MAKING AND USING | GEORGETOWN UNIVERSITY (US) | 2014-05-15 | — | — | US | disclosed |
| US-20140135325-A1 | NOVEL EZRIN INHIBITORS AND METHODS OF MAKING AND USING | GEORGETOWN UNIVERSITY (US) | 2014-05-15 | — | — | US | disclosed |
| US-20140107125-A1 | HYDRAZONOPYRAZOLE DERIVATIVES AND THEIR USE AS THERAPEUTICS | DERMIRA (CANADA), INC. (US) | 2014-04-17 | — | — | US | disclosed |
| US-20140107125-A1 | HYDRAZONOPYRAZOLE DERIVATIVES AND THEIR USE AS THERAPEUTICS | DERMIRA (CANADA), INC. (US) | 2014-04-17 | — | — | US | disclosed |
| US-20140107125-A1 | HYDRAZONOPYRAZOLE DERIVATIVES AND THEIR USE AS THERAPEUTICS | DERMIRA (CANADA), INC. (US) | 2014-04-17 | — | — | US | disclosed |
| US-8445694-B2 | Hydrazonopyrazole derivatives and their use as therapeutics | DERMIRA (CANADA), INC. (US) | 2013-05-21 | — | — | US | disclosed |
| US-8445694-B2 | Hydrazonopyrazole derivatives and their use as therapeutics | DERMIRA (CANADA), INC. (US) | 2013-05-21 | — | — | US | disclosed |
| US-7229753-B2 | Photothermographic material and method for forming images | FUJIFILM CORPORATION (JP) | 2007-06-12 | — | — | US | disclosed |
| US-7229753-B2 | Photothermographic material and method for forming images | FUJIFILM CORPORATION (JP) | 2007-06-12 | — | — | US | disclosed |
| US-20070003882-A9 | Photothermographic material, and image forming method using same | FUKUI KOUTA | 2007-01-04 | — | — | US | disclosed |
| US-20070003882-A9 | Photothermographic material, and image forming method using same | FUKUI KOUTA | 2007-01-04 | — | — | US | disclosed |
| WO-2006058338-A2 | 4 - PIPERIDINECARBOXAMIDE DERIVATIVES AS MODULATORS OF VANILLOID VR1 RECEPTOR | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-06-01 | — | — | WO | disclosed |
| US-20060116368-A1 | 4-Piperidinecarboxamide modulators of vanilloid VR1 receptor | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-06-01 | — | — | US | disclosed |
| US-20050272709-A1 | Immugenic compositions and diagnostic and therapeutic uses thereof | DERMIRA (CANADA), INC. | 2005-12-08 | — | — | US | disclosed |
| CN-1671379-A | Hydrazinopyrazole derivatives and their use as therapeutic agents | QUADRA LOGIC TECH INC (CA) | 2005-09-21 | — | — | CN | disclosed |
| EP-1450791-A1 | HYDRAZONOPYRAZOLE DERIVATIVES AND THEIR USE AS THERAPEUTICS | Kinetek Pharmaceuticals, Inc. (CA) | 2004-09-01 | — | — | EP | disclosed |
| WO-2003045379-A1 | HYDRAZONOPYRAZOLE DERIVATIVES AND THEIR USE AS THERAPEUTICS | KINETEK PHARMACEUTICALS, INC. (CA) | 2003-06-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140107125-A1 | HYDRAZONOPYRAZOLE DERIVATIVES AND THEIR USE AS THERAPEUTICS | CDK4, CCNI, BCL2 | ALDH1A1 1614/4885TDP1 646/4885NOS1 987/4885 |
| US-20180148437-A1 | Novel Ezrin Inhibitors and Methods of Making and Using | EZR, CDC42, ERMP1 | ALDH1A1 4430/4885TDP1 3654/4885NOS1 3626/4885 |
| US-20140135325-A1 | NOVEL EZRIN INHIBITORS AND METHODS OF MAKING AND USING | EZR, NHERF1, ERMP1 | ALDH1A1 4434/4885TDP1 3636/4885NOS1 3426/4885 |
| US-20050272709-A1 | Immugenic compositions and diagnostic and therapeutic uses thereof | MKI67, CDK4, CCNC | ALDH1A1 3393/4885TDP1 286/4885NOS1 1161/4885 |
| US-20060116368-A1 | 4-Piperidinecarboxamide modulators of vanilloid VR1 receptor | VDAC1, TRPV1, HVCN1 | ALDH1A1 1117/4885TDP1 4229/4885NOS1 4147/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.