Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 9/20 | 0.55 |
| ▸ | DRD2 | P14416 | 9/20 | 0.55 |
| ▸ | FAAH | O00519 | 3/20 | 0.55 |
| ▸ | CNR1 | P21554 | 2/20 | 0.55 |
| ▸ | DRD4 | P21917 | 4/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | SLC29A1 | Q99808 | 2/20 | 0.50 |
| ▸ | HTR2A | P28223 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | HTR2C | P28335 | 1/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.48 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9559698 | 0.89 | DRD2 (0.62) | DRD3DRD2TP53HTR2AMEN1 | |
| SCHEMBL9559709 | 0.88 | DRD2 (0.55) | DRD3DRD2DRD4TP53SLC29A1 | |
| SCHEMBL9229836 | 0.86 | MEN1 (0.52) | DRD3DRD2SLC29A1HTR2AMEN1 | |
| SCHEMBL9559731 | 0.81 | THRB (0.59) | DRD3DRD2DRD4TP53SLC29A1 | |
| SCHEMBL9132937 | 0.81 | SLC29A1 (0.70) | TP53SLC29A1HTR2AMEN1KMT2A | |
| SCHEMBL9559605 | 0.80 | TP53 (0.57) | DRD2DRD4TP53SLC29A1HTR2A | |
| SCHEMBL9223178 | 0.80 | TSHR (0.54) | DRD3DRD2DRD4TP53HTR2A | |
| SCHEMBL9226276 | 0.80 | ALDH1A1 (0.52) | DRD3DRD2DRD4HTR2AMEN1 | |
| SCHEMBL9559610 | 0.79 | TP53 (0.56) | TP53SLC29A1HTR2AMEN1KMT2A | |
| SCHEMBL9559630 | 0.79 | TP53 (0.56) | DRD2DRD4TP53SLC29A1HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0544765-B1 | Piperazinyl derivatives with affinity for 5-HT receptors | NOVO NORDISK AS (DK) | 1995-08-02 | — | — | EP | claimed |
| EP-0544765-A1 | PIPERAZINYL DERIVATIVES. | NOVO NORDISK AS (DK) | 1993-06-09 | — | — | EP | claimed |
| WO-1992003426-A1 | PIPERAZINYL DERIVATIVES | NOVO NORDISK A/S (DK) | 1992-03-05 | — | — | WO | claimed |
| EP-0544765-B1 | Piperazinyl derivatives with affinity for 5-HT receptors | NOVO NORDISK AS (DK) | 1995-08-02 | — | — | EP | disclosed |
| US-5246935-A | Cardiovascular and gastrointestinal | NOVO NORDISK A/S (DK) | 1993-09-21 | — | — | US | disclosed |
| EP-0544765-A1 | PIPERAZINYL DERIVATIVES. | NOVO NORDISK AS (DK) | 1993-06-09 | — | — | EP | disclosed |
| WO-1992003426-A1 | PIPERAZINYL DERIVATIVES | NOVO NORDISK A/S (DK) | 1992-03-05 | — | — | WO | disclosed |