Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 10/20 | 0.38 |
| ▸ | OTUD7B | Q6GQQ9 | 2/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 7/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 3/20 | 0.32 |
| ▸ | PRKCB | P05771 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9231150 | 0.87 | OPRL1 (0.35) | OPRL1OTUD7BOPRM1NPC1POLB | |
| SCHEMBL9230707 | 0.86 | AKR1C3 (0.38) | OPRL1OTUD7BCYP1A2BRD4 | |
| SCHEMBL9231629 | 0.81 | LMNA (0.42) | NPC1POLBCYP2D6TSHRSMN1; SMN2 | |
| SCHEMBL9231680 | 0.80 | CCR1 (0.33) | OPRL1OTUD7BOPRM1NPC1L3MBTL1 | |
| SCHEMBL9231434 | 0.80 | L3MBTL1 (0.34) | OTUD7BL3MBTL1SMN1; SMN2 | |
| SCHEMBL9231114 | 0.77 | AKR1C3 (0.42) | OPRL1OPRM1NPC1POLB | |
| SCHEMBL9225797 | 0.77 | OPRL1 (0.35) | OPRL1OPRM1NPC1POLBCYP2D6 | |
| SCHEMBL9232019 | 0.74 | ALDH1A1 (0.40) | OPRL1OPRM1NPC1POLBTSHR | |
| SCHEMBL9042112 | 0.74 | OPRL1 (0.33) | OPRL1OTUD7BOPRM1NPC1POLB | |
| SCHEMBL11842992 | 0.74 | BRD4 (0.40) | POLBCYP1A2SMN1; SMN2BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0640087-A1 | USE OF TRICYCLIC PYRIMIDINE DERIVATIVES AS ANTI-VIRAL MEDICAMENTS | Roche Diagnostics GmbH (DE) | 1995-03-01 | — | — | EP | disclosed |
| WO-1993023405-A1 | USE OF TRICYCLIC PYRIMIDINE DERIVATIVES AS ANTI-VIRAL MEDICAMENTS | BOEHRINGER MANNHEIM GMBH (DE) | 1993-11-25 | — | — | WO | disclosed |