Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 3/20 | 0.49 |
| ▸ | HRH1 | P35367 | 3/20 | 0.49 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 3/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.47 |
| ▸ | HTR1D | P28221 | 1/20 | 0.47 |
| ▸ | HTR1B | P28222 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 4/20 | 0.46 |
| ▸ | HTR2C | P28335 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 2/20 | 0.45 |
| ▸ | HTR7 | P34969 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9227826 | 0.95 | TSHR (0.51) | ADRA1AHRH1ADRA1BKCNH2HRH3 | |
| SCHEMBL9230859 | 0.87 | HTR1A (0.47) | KCNH2ALDH1A1KDM4EEPHX2HTR1A | |
| SCHEMBL9226276 | 0.86 | ALDH1A1 (0.52) | KCNH2HRH3ALDH1A1KDM4EHTT | |
| SCHEMBL9559588 | 0.83 | NPC1 (0.55) | ALDH1A1KDM4EEPHX2HTR2AGAA | |
| SCHEMBL9231699 | 0.82 | KCNH2 (0.49) | ADRA1AHRH1ADRA1BKCNH2HRH3 | |
| SCHEMBL9230400 | 0.82 | DRD2 (0.48) | ALDH1A1KDM4EEPHX2HTR1ASLC6A4 | |
| SCHEMBL9226202 | 0.82 | EPHX2 (0.51) | ALDH1A1HTTEPHX2HTR1AHTR1D | |
| SCHEMBL9229836 | 0.81 | MEN1 (0.52) | ADRA1AHRH1ADRA1BKCNH2HRH3 | |
| SCHEMBL9230829 | 0.81 | HTR1A (0.51) | ADRA1AHRH1ADRA1BALDH1A1KDM4E | |
| SCHEMBL9223178 | 0.80 | TSHR (0.54) | KCNH2HRH3ALDH1A1HTTEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0544765-B1 | Piperazinyl derivatives with affinity for 5-HT receptors | NOVO NORDISK AS (DK) | 1995-08-02 | — | — | EP | disclosed |
| US-5246935-A | Cardiovascular and gastrointestinal | NOVO NORDISK A/S (DK) | 1993-09-21 | — | — | US | disclosed |
| WO-1992003426-A1 | PIPERAZINYL DERIVATIVES | NOVO NORDISK A/S (DK) | 1992-03-05 | — | — | WO | disclosed |