Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.48 |
| ▸ | DRD4 | P21917 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 2/20 | 0.46 |
| ▸ | HTR1D | P28221 | 1/20 | 0.46 |
| ▸ | HTR1B | P28222 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9227703 | 0.95 | MAPT (0.49) | DRD2DRD4HTR1AHTR1DHTR1B | |
| SCHEMBL9226276 | 0.87 | ALDH1A1 (0.52) | DRD2DRD4HTR1AEPHX2ALDH1A1 | |
| SCHEMBL9230359 | 0.82 | ADRA1A (0.49) | DRD2HTR1AHTR1DHTR1BSLC6A4 | |
| SCHEMBL9223178 | 0.81 | TSHR (0.54) | DRD2DRD4HTR1AEPHX2ALDH1A1 | |
| SCHEMBL9230859 | 0.81 | HTR1A (0.47) | DRD2HTR1AHTR1DHTR1BEPHX2 | |
| SCHEMBL9559588 | 0.80 | NPC1 (0.55) | DRD2EPHX2ALDH1A1KDM4EMEN1 | |
| SCHEMBL9224851 | 0.80 | ALDH1A1 (0.50) | EPHX2ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL9559847 | 0.80 | TSHR (0.51) | DRD2HTR1AHTR1DHTR1BEPHX2 | |
| SCHEMBL9230829 | 0.78 | HTR1A (0.51) | DRD2DRD4HTR1AHTR1DHTR1B | |
| SCHEMBL9225187 | 0.78 | ALDH1A1 (0.47) | DRD2DRD4HTR1AEPHX2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0544765-B1 | Piperazinyl derivatives with affinity for 5-HT receptors | NOVO NORDISK AS (DK) | 1995-08-02 | — | — | EP | disclosed |
| US-5246935-A | Cardiovascular and gastrointestinal | NOVO NORDISK A/S (DK) | 1993-09-21 | — | — | US | disclosed |
| EP-0544765-A1 | PIPERAZINYL DERIVATIVES. | NOVO NORDISK AS (DK) | 1993-06-09 | — | — | EP | disclosed |
| WO-1992003426-A1 | PIPERAZINYL DERIVATIVES | NOVO NORDISK A/S (DK) | 1992-03-05 | — | — | WO | disclosed |