Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 4/20 | 0.47 |
| ▸ | HTR1D | P28221 | 2/20 | 0.47 |
| ▸ | HTR1B | P28222 | 2/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 4/20 | 0.44 |
| ▸ | HTR2A | P28223 | 3/20 | 0.44 |
| ▸ | HTR7 | P34969 | 3/20 | 0.44 |
| ▸ | DRD3 | P35462 | 2/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9226202 | 0.95 | EPHX2 (0.51) | HTR1AHTR1DHTR1BEPHX2ALDH1A1 | |
| SCHEMBL9559847 | 0.90 | TSHR (0.51) | HTR1AHTR1DHTR1BEPHX2ALDH1A1 | |
| SCHEMBL9230359 | 0.87 | ADRA1A (0.49) | HTR1AHTR1DHTR1BEPHX2ALDH1A1 | |
| SCHEMBL9226276 | 0.87 | ALDH1A1 (0.52) | HTR1AEPHX2ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL9224851 | 0.83 | ALDH1A1 (0.50) | EPHX2ALDH1A1KDM4ERECQLSMN1; SMN2 | |
| SCHEMBL9227826 | 0.82 | TSHR (0.51) | HTR1AHTR1DHTR1BEPHX2ALDH1A1 | |
| SCHEMBL9559588 | 0.82 | NPC1 (0.55) | EPHX2ALDH1A1KDM4ESMN1; SMN2NPC1 | |
| SCHEMBL9223178 | 0.81 | TSHR (0.54) | HTR1AEPHX2ALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL9230400 | 0.81 | DRD2 (0.48) | HTR1AHTR1DHTR1BEPHX2ALDH1A1 | |
| SCHEMBL9230829 | 0.80 | HTR1A (0.51) | HTR1AHTR1DHTR1BEPHX2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0544765-B1 | Piperazinyl derivatives with affinity for 5-HT receptors | NOVO NORDISK AS (DK) | 1995-08-02 | — | — | EP | disclosed |
| US-5246935-A | Cardiovascular and gastrointestinal | NOVO NORDISK A/S (DK) | 1993-09-21 | — | — | US | disclosed |
| WO-1992003426-A1 | PIPERAZINYL DERIVATIVES | NOVO NORDISK A/S (DK) | 1992-03-05 | — | — | WO | disclosed |