Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.36 |
| ▸ | BACE1 | P56817 | 4/20 | 0.36 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.36 |
| ▸ | HTR3B | O95264 | 1/20 | 0.36 |
| ▸ | HTR3A | P46098 | 1/20 | 0.36 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.36 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.35 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9229909 | 0.83 | KMT2A (0.48) | BACE1 | |
| SCHEMBL9225639 | 0.81 | BACE1 (0.43) | HTR6BACE1HTR3EHTR3BHTR3A | |
| SCHEMBL27434832 | 0.77 | ALDH1A1 (0.42) | HTR6BACE1 | |
| SCHEMBL23256392 | 0.71 | ADRB1 (0.56) | HTR6HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL9229904 | 0.66 | ADRB1 (0.51) | HTR6BACE1HTR3EHTR3BHTR3A | |
| SCHEMBL9231899 | 0.66 | HTR2A (0.48) | HTR6BACE1HTR3EHTR3BHTR3A | |
| SCHEMBL9227346 | 0.66 | DRD2 (0.48) | BACE1 | |
| Hydrochloric Acid SCHEMBL9229290 | 0.65 | ADRB1 (0.50) | HTR6BACE1HTR3EHTR3BHTR3A | |
| SCHEMBL9229883 | 0.65 | PRKDC (0.52) | HTR6PDE3BPDE3AHTR3EHTR3B | |
| Hydrochloric Acid SCHEMBL9230090 | 0.65 | DRD2 (0.47) | BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0650964-A1 | 1 2H-1-benzopyran-2-one-8-yl -piperazine derivatives | DUPHAR INTERNATIONAL RESEARCH B.V (NL) | 1995-05-03 | — | — | EP | disclosed |