Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 known ✓ | Q9Y5N1 | 4/20 | 0.42 |
| ▸ | HRH1 known ✓ | P35367 | 1/20 | 0.41 |
| ▸ | LSS | P48449 | 3/20 | 0.48 |
| ▸ | NAMPT | P43490 | 3/20 | 0.46 |
| ▸ | BCHE | P06276 | 3/20 | 0.43 |
| ▸ | ACHE | P22303 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL9230988 | 1.00 | LSS (0.48) | LSSNAMPTBCHEACHEHRH3 | |
| Fumaric Acid SCHEMBL9232176 | 0.88 | GSK3B (0.42) | LSSBCHEACHEHRH1KDM4E | |
| Maleic Acid SCHEMBL9232171 | 0.88 | GSK3B (0.42) | LSSBCHEACHEHRH1KDM4E | |
| Maleic Acid SCHEMBL9230995 | 0.88 | LSS (0.45) | LSSBCHEACHEHRH1KDM4E | |
| Fumaric Acid SCHEMBL9231005 | 0.88 | LSS (0.45) | LSSBCHEACHEHRH1KDM4E | |
| Fumaric Acid SCHEMBL10591933 | 0.87 | LSS (0.41) | LSSBCHEACHEHRH3SMN1; SMN2 | |
| Fumaric Acid SCHEMBL9234273 | 0.86 | LSS (0.41) | LSSNAMPTBCHEACHESMN1; SMN2 | |
| Fumaric Acid SCHEMBL9234267 | 0.86 | LSS (0.41) | LSSNAMPTBCHEACHESMN1; SMN2 | |
| Fumaric Acid SCHEMBL9237908 | 0.86 | ALDH1A1 (0.48) | LSSBCHEACHESMN1; SMN2HRH1 | |
| Maleic Acid SCHEMBL9237900 | 0.86 | ALDH1A1 (0.48) | LSSBCHEACHESMN1; SMN2HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0641564-A1 | OPTICALLY ACTIVE CONDENSED PYRAZOLE COMPOUND FOR USE IN TREATING THROMBOCYTOPENIA AND ERYTHROPENIA | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1995-03-08 | — | — | EP | disclosed |
| EP-0338087-A1 | FUSED PYRAZOLE COMPOUNDS, PROCESS FOR THEIR PREPARATION, AND THEIR MEDICINAL USE | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1989-10-25 | — | — | EP | disclosed |