Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.57 |
| ▸ | MEN1 | O00255 | 4/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 4/20 | 0.48 |
| ▸ | RAB9A | P51151 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | CCR5 | P51681 | 4/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.45 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.45 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9238331 | 0.87 | MLYCD (0.53) | KMT2ASMN1; SMN2MEN1ALDH1A1NR1H4 | |
| SCHEMBL9236562 | 0.85 | NR1H4 (0.65) | KMT2ASMN1; SMN2MEN1ALDH1A1NR1H4 | |
| SCHEMBL9237286 | 0.83 | SMN1; SMN2 (0.54) | KMT2ASMN1; SMN2MEN1ALDH1A1NR1H4 | |
| Hydrochloric Acid SCHEMBL9232743 | 0.82 | SMN1; SMN2 (0.53) | KMT2ASMN1; SMN2MEN1ALDH1A1NR1H4 | |
| SCHEMBL8185146 | 0.78 | KMT2A (0.74) | KMT2ASMN1; SMN2MEN1ALDH1A1NR1H4 | |
| SCHEMBL9238430 | 0.77 | KMT2A (0.51) | KMT2ASMN1; SMN2MEN1ALDH1A1LMNA | |
| SCHEMBL28399828 | 0.76 | HDAC8 (0.56) | KMT2AALDH1A1NPC1RAB9ATHRB | |
| SCHEMBL6592666 | 0.76 | KMT2A (0.58) | KMT2ASMN1; SMN2MEN1ALDH1A1NR1H4 | |
| SCHEMBL9253364 | 0.75 | CYP11B1 (0.52) | KMT2AMEN1ALDH1A1MAPTRAB9A | |
| SCHEMBL393227 | 0.74 | EPHX2 (0.56) | KMT2ASMN1; SMN2MEN1ALDH1A1NR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0638553-A1 | Carboxylic acid amides having a terminal carboxylic acid group as aggregation inhibiting drugs | Dr. Karl Thomae GmbH (DE) | 1995-02-15 | — | — | EP | disclosed |