Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.54 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | CCR5 | P51681 | 5/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.48 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.48 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5567796 | 0.85 | ADRB2 (0.51) | LMNAMAPTALDH1A1EPHX2POLB | |
| Hydrochloric Acid SCHEMBL9232743 | 0.85 | SMN1; SMN2 (0.53) | SMN1; SMN2NR1H4LMNAMAPTKDM4E | |
| SCHEMBL2021051 | 0.83 | MEN1 (0.57) | SMN1; SMN2NR1H4LMNAKDM4ENPC1 | |
| SCHEMBL21674204 | 0.83 | MEN1 (0.57) | SMN1; SMN2NR1H4LMNAKDM4ENPC1 | |
| SCHEMBL9238331 | 0.83 | MLYCD (0.53) | SMN1; SMN2NR1H4LMNAMAPTKDM4E | |
| SCHEMBL9237156 | 0.83 | KMT2A (0.57) | SMN1; SMN2NR1H4LMNAMAPTKDM4E | |
| SCHEMBL2894685 | 0.82 | NPC1 (0.65) | SMN1; SMN2LMNAMAPTKDM4ENPC1 | |
| SCHEMBL4050326 | 0.81 | NPC1 (0.76) | SMN1; SMN2LMNAMAPTKDM4ENPC1 | |
| SCHEMBL20709767 | 0.79 | RAB9A (0.73) | SMN1; SMN2LMNAMAPTKDM4ENPC1 | |
| SCHEMBL12440876 | 0.79 | NR1H4 (0.62) | SMN1; SMN2NR1H4LMNAKDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0638553-A1 | Carboxylic acid amides having a terminal carboxylic acid group as aggregation inhibiting drugs | Dr. Karl Thomae GmbH (DE) | 1995-02-15 | — | — | EP | disclosed |