Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 7/20 | 0.48 |
| ▸ | MTNR1B | P49286 | 7/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9237392 | 0.99 | MTNR1A (0.47) | MTNR1AMTNR1BSIGMAR1CHRM2CHRM1 | |
| SCHEMBL9240092 | 0.81 | MTNR1A (0.50) | MTNR1AMTNR1BSIGMAR1CHRM2CHRM1 | |
| SCHEMBL3732776 | 0.81 | SIGMAR1 (0.54) | MTNR1AMTNR1BSIGMAR1CHRM2CHRM1 | |
| Hydrochloric Acid SCHEMBL9238517 | 0.80 | MTNR1A (0.49) | MTNR1AMTNR1BSIGMAR1CHRM2CHRM1 | |
| SCHEMBL8970307 | 0.75 | MTNR1A (0.62) | MTNR1AMTNR1BSIGMAR1CHRM2CHRM1 | |
| SCHEMBL8970407 | 0.74 | SIGMAR1 (0.53) | MTNR1AMTNR1BSIGMAR1CHRM2CHRM1 | |
| SCHEMBL2051475 | 0.74 | ALDH1A1 (0.49) | MTNR1AMTNR1BCHRM2CHRM1CHRM3 | |
| SCHEMBL12635378 | 0.73 | CHRM2 (0.62) | MTNR1AMTNR1BSIGMAR1CHRM2CHRM1 | |
| SCHEMBL12634890 | 0.72 | CHRM2 (0.60) | MTNR1AMTNR1BSIGMAR1CHRM2CHRM1 | |
| SCHEMBL8972304 | 0.71 | MTNR1A (0.49) | MTNR1AMTNR1BCHRM2CHRM1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5463105-A | Therapy for cardiovascular, nervous system disorders | BAYER AKTIENGESELLSCHAFT (DE) | 1995-10-31 | — | — | US | disclosed |
| US-5298513-A | Serotonin antagonist | BAYER AKTIENGESELLSCHAFT (DE) | 1994-03-29 | — | — | US | disclosed |
| US-5153225-A | For treating disorders of the central nervous system, cardiovascular system and intestinal tract | BAYER AKTIENGESELLSCHAFT (DE) | 1992-10-06 | — | — | US | disclosed |
| US-5026857-A | Cetnral nervous system disorders; antiserotonine agent | BAYER AKTIENGESELLSCHAFT (DE) | 1991-06-25 | — | — | US | disclosed |
| US-4880802-A | CENTRAL NERVOUS SYSTEM | BAYER AKTIENGESELLSCHAFT (DE) | 1989-11-14 | — | — | US | disclosed |