SCHEMBL9239223

SCHEMBL9239223

CSc1c(C(=O)CC(=O)C2CC2)ccc2c1OCO2

nearest known ligand 0.38

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
MTNR1A P48039 1/20 0.38
MTNR1B P49286 1/20 0.38
SMN1; SMN2 Q16637 3/20 0.37
KDM4E B2RXH2 2/20 0.37
NPSR1 Q6W5P4 1/20 0.37
AOC3 Q16853 1/20 0.36
ALDH1A1 P00352 1/20 0.36
NPC1 O15118 2/20 0.35
RAB9A P51151 2/20 0.35
POLB P06746 1/20 0.35
MAPT P10636 1/20 0.35
NFKB1 P19838 1/20 0.35
NFKB2 Q00653 1/20 0.35
RELA Q04206 1/20 0.35
HPGD P15428 2/20 0.34
KMT2A Q03164 4/20 0.34
MEN1 O00255 3/20 0.34
ACVRL1 P37023 3/20 0.34
MAOB P27338 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6183171 0.83 MTNR1A (0.40) MTNR1AMTNR1BSMN1; SMN2KDM4ENPSR1
SCHEMBL6182187 0.80 IDO1 (0.32) SMN1; SMN2KDM4EALDH1A1
SCHEMBL6184460 0.79 MTNR1A (0.38) MTNR1AMTNR1BSMN1; SMN2KDM4ENPSR1
SCHEMBL9118552 0.78 ACVRL1 (0.43) MTNR1AMTNR1BSMN1; SMN2KDM4ENPSR1
SCHEMBL6182096 0.77 AOC3 (0.39) MTNR1AMTNR1BSMN1; SMN2KDM4ENPSR1
SCHEMBL6186035 0.77 ALDH1A1 (0.41) SMN1; SMN2AOC3ALDH1A1NPC1RAB9A
Hydrochloric Acid SCHEMBL6183669 0.76 ALDH1A1 (0.40) SMN1; SMN2AOC3ALDH1A1NPC1RAB9A
SCHEMBL6183667 0.76 AOC3 (0.39) MTNR1AMTNR1BSMN1; SMN2AOC3ALDH1A1
SCHEMBL8389663 0.75 SMN1; SMN2 (0.36) SMN1; SMN2KDM4EALDH1A1NPC1RAB9A
SCHEMBL8490848 0.75 NPC1 (0.36) ALDH1A1NPC1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1995025099-A1 2-CYANO-1,3-DIONE DERIVATIVES USEFUL AS HERBICIDES RHONE-POULENC AGRICULTURE LTD. (GB) 1995-09-21 WO disclosed