Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.53 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.44 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.44 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.44 |
| ▸ | RXRA | P19793 | 2/20 | 0.42 |
| ▸ | RXRB | P28702 | 2/20 | 0.42 |
| ▸ | RXRG | P48443 | 2/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 2/20 | 0.42 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27660142 | 0.85 | HSD11B1 (0.62) | HSD11B1TRPA1TRPM8TRPV1S1PR1 | |
| SCHEMBL4654446 | 0.84 | RXRA (0.47) | HSD11B1TRPA1RXRARXRBRXRG | |
| SCHEMBL10979587 | 0.82 | HSD11B1 (0.44) | HSD11B1TRPA1TRPM8TRPV1IDO1 | |
| SCHEMBL1685381 | 0.82 | LTA4H (0.46) | HSD11B1RXRARXRBRXRGPPARG | |
| SCHEMBL6371363 | 0.81 | TDP1 (0.47) | HSD11B1RXRARXRBRXRGALDH1A1 | |
| SCHEMBL28098554 | 0.81 | HSD11B1 (0.42) | HSD11B1TRPA1TRPM8TRPV1RXRA | |
| SCHEMBL13020168 | 0.81 | HSD11B1 (0.42) | HSD11B1RXRARXRBRXRGPPARG | |
| SCHEMBL9871232 | 0.81 | ADRA2A (0.41) | HSD11B1RXRARXRBRXRGPPARG | |
| SCHEMBL10922032 | 0.81 | PPARG (0.40) | HSD11B1RXRARXRBRXRGPPARG | |
| SCHEMBL10417860 | 0.81 | MPL (0.43) | HSD11B1TRPA1TRPM8TRPV1IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109790200-A | For treating the azasteroid of tuberculosis | 纽约州立大学研究基金会 | 2019-05-21 | — | — | CN | claimed |
| CN-102895230-A | Antituberculous composition comprising oxazole compounds | OTSUKA PHARMA CO LTD | 2013-01-30 | — | — | CN | disclosed |
| CN-101277740-B | Antituberculous composition comprising azole compound | OTSUKA PHARMA CO LTD | 2012-12-05 | — | — | CN | disclosed |
| CN-101277740-A | Antituberculous compositions comprising * azole compounds | OTSUKA PHARMA CO LTD (JP) | 2008-10-01 | — | — | CN | disclosed |
| EP-0481317-B1 | Method for dechlorination and/or debromination of aromatic compounds containing fluorine with chlorine and/or bromine | BAYER AG (DE) | 1995-08-09 | — | — | EP | disclosed |
| US-5283378-A | Process for the dechlorination and/or debromination of fluorine-and chlorine- and/or bromine-containing aromatic compounds | BAYER AKTIENGESELLSCHAFT (DE) | 1994-02-01 | — | — | US | disclosed |
| EP-0481317-A2 | Method for dechlorination and/or debromination of aromatic compounds containing fluorine with chlorine and/or bromine | BAYER AG (DE) | 1992-04-22 | — | — | EP | disclosed |
| EP-0180818-A2 | Benzoyl ureas and intermediates | BAYER AG (DE) | 1986-05-14 | — | — | EP | disclosed |