Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HNF4A | P41235 | 1/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.48 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.48 |
| ▸ | PTPN6 | P29350 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ASPH | Q12797 | 3/20 | 0.41 |
| ▸ | RIOX2 | Q8IUF8 | 3/20 | 0.41 |
| ▸ | KDM8 | Q8N371 | 3/20 | 0.41 |
| ▸ | KDM4A | O75164 | 1/20 | 0.41 |
| ▸ | KDM5A | P29375 | 1/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.41 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13850877 | 0.80 | HNF4A (0.54) | HNF4APTPN1PTPN2PTPN6ALDH1A1 | |
| SCHEMBL11630337 | 0.77 | PTPN1 (0.45) | HNF4APTPN1PTPN2PTPN6ALDH1A1 | |
| SCHEMBL13851063 | 0.76 | KDM4E (0.46) | HNF4APTPN1PTPN2PTPN6ALDH1A1 | |
| SCHEMBL19857480 | 0.74 | GABRP (0.46) | ALDH1A1NPC1KDM4EGABRPGABRD | |
| SCHEMBL11623244 | 0.74 | GABRP (0.46) | ALDH1A1HPGDNPC1KDM4EGABRP | |
| SCHEMBL13851064 | 0.73 | KDM4E (0.48) | ALDH1A1NPC1KDM4ELMNAGABRA1 | |
| SCHEMBL23566852 | 0.72 | AGBL2 (0.51) | NPC1KDM4EASPHKDM8KDM4C | |
| SCHEMBL924177 | 0.72 | GABRP (0.45) | ALDH1A1HTTNPC1KDM4EGABRP | |
| SCHEMBL24365134 | 0.72 | GABRP (0.53) | PTPN1ALDH1A1HPGDNPC1KDM4E | |
| SCHEMBL11630841 | 0.72 | RNASEH1 (0.42) | HNF4APTPN1PTPN2PTPN6ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8163766-B2 | Beta-secretase modulators and methods of use | AMGEN INC. (US) | 2012-04-24 | — | — | US | disclosed |
| US-20110118250-A1 | BETA-SECRETASE MODULATORS AND METHODS OF USE | AMGEN INC. (US) | 2011-05-19 | — | — | US | disclosed |
| US-7872009-B2 | Beta-Secretase modulators and methods of use | AMGEN INC. (US) | 2011-01-18 | — | — | US | disclosed |
| EP-1954693-A1 | BETA-SECRETASE MODULATORS AND METHODS OF USE | Amgen Inc. (US) | 2008-08-13 | — | — | EP | disclosed |
| US-20070185103-A1 | Beta-secretase modulators and methods of use | AMGEN INC. | 2007-08-09 | — | — | US | disclosed |
| WO-2007062007-A1 | BETA-SECRETASE MODULATORS AND METHODS OF USE | AMGEN INC. (US) | 2007-05-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110118250-A1 | BETA-SECRETASE MODULATORS AND METHODS OF USE | BACE1, BACE2, APP | HNF4A 2609/4885PTPN1 4582/4885PTPN2 4621/4885 |
| US-20070185103-A1 | Beta-secretase modulators and methods of use | BACE1, BACE2, APP | HNF4A 2609/4885PTPN1 4582/4885PTPN2 4621/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.