SCHEMBL924438

SCHEMBL924438

c1ccc2[nH]c(-c3nc4ccccc4[nH]3)cc2c1

nearest known ligand 0.71

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 3/20 0.71
NPC1 O15118 10/20 0.64
RAB9A P51151 10/20 0.64
ALDH1A1 P00352 9/20 0.64
SMN1; SMN2 Q16637 7/20 0.64
KDM4E B2RXH2 7/20 0.64
HSD17B10 Q99714 6/20 0.64
TP53 P04637 4/20 0.64
PKM P14618 4/20 0.64
NPSR1 Q6W5P4 2/20 0.64
ABCB11 O95342 1/20 0.64
KDR P35968 2/20 0.61
PDGFRB P09619 1/20 0.61
FGFR1 P11362 1/20 0.61
AURKA O14965 1/20 0.57
CDK1 P06493 1/20 0.57
CDK2 P24941 1/20 0.57
AURKB Q96GD4 1/20 0.57
GAA P10253 2/20 0.56
HPGD P15428 6/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28633752 0.80 KDR (0.56) ESR1NPC1RAB9AALDH1A1SMN1; SMN2
SCHEMBL4497587 0.80 TNKS (0.59) ESR1NPC1RAB9AALDH1A1KDM4E
SCHEMBL30561047 0.80 NPC1 (1.00) NPC1RAB9AALDH1A1SMN1; SMN2KDM4E
SCHEMBL30634854 0.80 NPC1 (1.00) NPC1RAB9AALDH1A1SMN1; SMN2KDM4E
SCHEMBL172216 0.80 NPC1 (1.00) NPC1RAB9AALDH1A1SMN1; SMN2KDM4E
SCHEMBL27635441 0.78 KDM4E (0.57) NPC1RAB9AALDH1A1SMN1; SMN2KDM4E
SCHEMBL4736411 0.78 KDR (0.53) ESR1NPC1RAB9AALDH1A1SMN1; SMN2
Water SCHEMBL9817804 0.78 NPC1 (0.95) NPC1RAB9AALDH1A1SMN1; SMN2KDM4E
SCHEMBL29631691 0.77 RAB9A (0.74) ESR1NPC1RAB9AALDH1A1SMN1; SMN2
SCHEMBL374022 0.77 RAB9A (0.74) ESR1NPC1RAB9AALDH1A1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 213 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115215839-B Indolyl benzimidazole near-infrared fluorescent dye and preparation method and application thereof 南京林业大学 2023-10-20 CN claimed
CN-115215839-A Indolyl benzimidazole near-infrared fluorescent dye and preparation method and application thereof 南京林业大学 2022-10-21 CN claimed
EP-1028120-B1 Organosilicon compounds with N-substituted benzimidazole-benzazole or benzofuranyl-benzazole groups, sunscreen compositions containing these compounds and their use OREAL (FR) 2003-03-19 EP claimed
US-20020172647-A1 Composition containing a steroid and a liposoluble UV filter L'OREAL (FR) 2002-11-21 US claimed
EP-1221933-A2 COMPOSITION, ESPECIALLY A COSMETIC COMPOSITION, CONTAINING A STEROID AND A LIPOSOLUBLE UV FILTER L'OREAL (FR) 2002-07-17 EP claimed
US-6221343-B1 Benzimidazole/benzofuryl-benzazole silicon compounds and UV-photoprotective compositions comprised thereof SOCIETE L'OREAL S.A. (FR) 2001-04-24 US claimed
WO-2001026618-A2 COMPOSITION, ESPECIALLY A COSMETIC COMPOSITION, CONTAINING A STEROID AND A LIPOSOLUBLE UV FILTER L'OREAL (FR) 2001-04-19 WO claimed
EP-1028120-A1 Organosilicon compounds with N-substituted benzimidazole-benzazole or benzofuranyl-benzazole groups, sunscreen compositions containing these compounds and their use L'OREAL (FR) 2000-08-16 EP claimed
EP-3709966-B1 COMPOSITIONS COMPRISING AT LEAST ONE ACRYLIC POLYMER AND AT LEAST ONE INSOLUBLE ORGANIC SCREENING AGENT OREAL (FR) 2024-12-11 EP disclosed
EP-3700909-B1 MATERIALS FOR ORGANIC ELECTROLUMINESCENT DEVICES MERCK PATENT GMBH (DE) 2024-01-24 EP disclosed
EP-2938324-B1 LIQUID TOPICAL PHARMACEUTICAL NANO-EMULSION FORMULATIONS JRX BIOTECHNOLOGY INC (US) 2023-11-08 EP disclosed
CN-115215839-B Indolyl benzimidazole near-infrared fluorescent dye and preparation method and application thereof 南京林业大学 2023-10-20 CN disclosed
CN-115215839-B Indolyl benzimidazole near-infrared fluorescent dye and preparation method and application thereof 南京林业大学 2023-10-20 CN disclosed
CN-115215839-B Indolyl benzimidazole near-infrared fluorescent dye and preparation method and application thereof 南京林业大学 2023-10-20 CN disclosed
EP-1203789-A1 Composition comprising a mixed silicate, polysacharide and crosslinked polymer and its utilisation L'OREAL (FR) 2002-05-08 EP disclosed
US-6221343-B1 Benzimidazole/benzofuryl-benzazole silicon compounds and UV-photoprotective compositions comprised thereof SOCIETE L'OREAL S.A. (FR) 2001-04-24 US disclosed
WO-2001026618-A2 COMPOSITION, ESPECIALLY A COSMETIC COMPOSITION, CONTAINING A STEROID AND A LIPOSOLUBLE UV FILTER L'OREAL (FR) 2001-04-19 WO disclosed
WO-2000078761-A1 INDOLYL-BENZIMIDAZOLE ANTIBACTERIALS, AND METHODS OF USE THEREOF SEPRACOR, INC. (US) 2000-12-28 WO disclosed
EP-1028120-A1 Organosilicon compounds with N-substituted benzimidazole-benzazole or benzofuranyl-benzazole groups, sunscreen compositions containing these compounds and their use L'OREAL (FR) 2000-08-16 EP disclosed
EP-1028120-A1 Organosilicon compounds with N-substituted benzimidazole-benzazole or benzofuranyl-benzazole groups, sunscreen compositions containing these compounds and their use L'OREAL (FR) 2000-08-16 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020172647-A1 Composition containing a steroid and a liposoluble UV filter SHBG, GLA, LIPA ESR1 2066/4885NPC1 1587/4885RAB9A 4027/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.