Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPEPPS | P55786 | 1/20 | 0.43 |
| ▸ | SLC11A2 | P49281 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | NOS2 | P35228 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20028551 | 0.85 | NPEPPS (0.39) | NPEPPSRAB9ATP53HPGDALDH1A1 | |
| SCHEMBL4986818 | 0.81 | RAB9A (0.43) | NPEPPSRAB9ANPC1ALDH1A1MAPT | |
| SCHEMBL4986575 | 0.81 | CRBN (0.41) | HPGDALDH1A1KDM4EMAPTHSD17B10 | |
| SCHEMBL29661865 | 0.81 | CYP2C19 (0.44) | NPEPPSTP53ALDH1A1KDM4EMAPT | |
| SCHEMBL951112 | 0.81 | CYP2C19 (0.44) | NPEPPSTP53ALDH1A1KDM4EMAPT | |
| SCHEMBL29661868 | 0.81 | CYP2C19 (0.44) | NPEPPSTP53ALDH1A1KDM4EMAPT | |
| SCHEMBL16652517 | 0.78 | NPEPPS (0.50) | NPEPPSRAB9ANPC1ALDH1A1KDM4E | |
| SCHEMBL29824417 | 0.77 | CTSB (0.49) | RAB9ANPC1ALDH1A1MAPTMAPK1 | |
| SCHEMBL28827456 | 0.77 | CTSB (0.49) | RAB9ANPC1ALDH1A1MAPTMAPK1 | |
| SCHEMBL4984554 | 0.77 | ALDH1A1 (0.47) | HPGDALDH1A1KDM4EMAPTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111440144-A | Method for industrially producing bromopyrazolic acid through micro-channel | 山东华科化工有限公司 | 2020-07-24 | — | — | CN | claimed |
| CN-111440144-A | Method for industrially producing bromopyrazolic acid through micro-channel | 山东华科化工有限公司 | 2020-07-24 | — | — | CN | disclosed |
| EP-1417175-B1 | SUBSTITUTED DIHYDRO 3-HALO-1H-PYRAZOLE-5-CARBOXYLATES, THEIR PREPARATION AND USE | DU PONT (US) | 2013-07-24 | — | — | EP | disclosed |
| US-7402676-B2 | Substituted dihydro 3-halo-1H-pyrazole-5-carboxylates their preparation and use | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2008-07-22 | — | — | US | disclosed |
| US-20070203342-A1 | Subtituted dihydro 3-halo-1H-pyrazole-5-carboxylates their preparation and use | FMC CORPORATION | 2007-08-30 | — | — | US | disclosed |
| US-7227025-B2 | Substituted dihydro 3-halo-1H-pyrazole-T-carboxylates, their preparation and use | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2007-06-05 | — | — | US | disclosed |
| US-6965032-B2 | Substituted dihydro 3-halo-1h-pyrazole-5-carboxylates and their preparation and use | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2005-11-15 | — | — | US | disclosed |
| US-20050245580-A1 | Halogenation and oxidation of a 5-carboxyl-3-oxo-1-aryl-substituted-1H-pyrazolidine | FMC CORPORATION | 2005-11-03 | — | — | US | disclosed |
| US-20040198987-A1 | Substituted dihydro 3-halo-1h-pyrazole-5-carboxylates their preparation and use | FMC CORPORATION | 2004-10-07 | — | — | US | disclosed |
| EP-1417175-A1 | SUBSTITUTED DIHYDRO 3-HALO-1H-PYRAZOLE-5-CARBOXYLATES, THEIR PREPARATION AND USE | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2004-05-12 | — | — | EP | disclosed |
| WO-2003016283-A1 | SUBSTITUTED DIHYDRO 3-HALO-1H-PYRAZOLE-5-CARBOXYLATES THEIR PREPARATION AND USE | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2003-02-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040198987-A1 | Substituted dihydro 3-halo-1h-pyrazole-5-carboxylates their preparation and use | CBR3, CBR1, CYP2F1 | NPEPPS 4574/4885SLC11A2 4169/4885RAB9A 188/4885 |
| US-20070203342-A1 | Subtituted dihydro 3-halo-1H-pyrazole-5-carboxylates their preparation and use | CBR3, CBR1, DHRS9 | NPEPPS 4509/4885SLC11A2 4243/4885RAB9A 221/4885 |
| US-20050245580-A1 | Halogenation and oxidation of a 5-carboxyl-3-oxo-1-aryl-substituted-1H-pyrazolidine | CBR3, CBR1, CYP2F1 | NPEPPS 4590/4885SLC11A2 3135/4885RAB9A 494/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.