Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 10/20 | 0.67 |
| ▸ | TACR1 | P25103 | 7/20 | 0.67 |
| ▸ | SLC6A2 | P23975 | 8/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.47 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL923866 | 0.87 | TACR1 (0.55) | SLC6A4TACR1SLC6A2SLC6A3KCNH2 | |
| SCHEMBL8569135 | 0.86 | SLC6A4 (0.72) | SLC6A4TACR1SLC6A2SLC6A3KCNH2 | |
| SCHEMBL926471 | 0.85 | SLC6A4 (0.51) | SLC6A4TACR1SLC6A2SLC6A3KCNH2 | |
| SCHEMBL924025 | 0.82 | TACR1 (0.49) | SLC6A4TACR1SLC6A2SLC6A3KCNH2 | |
| SCHEMBL3039337 | 0.80 | PDK1 (0.48) | SLC6A4TACR1SLC6A2SLC6A3KCNH2 | |
| SCHEMBL926462 | 0.79 | OPRM1 (0.61) | SLC6A4SLC6A2SLC6A3KCNH2OPRD1 | |
| SCHEMBL23256449 | 0.79 | TACR1 (0.49) | SLC6A4TACR1SLC6A2SLC6A3KCNH2 | |
| SCHEMBL3038017 | 0.79 | SLC6A4 (0.54) | SLC6A4TACR1SLC6A2SLC6A3KCNH2 | |
| Hydrochloric Acid SCHEMBL3631089 | 0.78 | OPRM1 (0.60) | SLC6A4SLC6A2SLC6A3KCNH2OPRD1 | |
| SCHEMBL924001 | 0.78 | MC4R (0.49) | SLC6A4TACR1SLC6A2SLC6A3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110009449-A1 | N-ARYL-N-PIPERIDIN-4-YL-PROPIONAMIDE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS | NEUROSEARCH A/S (DK) | 2011-01-13 | — | — | US | claimed |
| US-20110046180-A1 | N-ARYL-N-PIPERIDIN-4-YL-PROPIONAMIDE DERIVATIVES AND THEIR USE AS OPIOID RECEPTOR LIGANDS | NEUROSEARCH A/S (DK) | 2011-02-24 | — | — | US | disclosed |
| US-20110046180-A1 | N-ARYL-N-PIPERIDIN-4-YL-PROPIONAMIDE DERIVATIVES AND THEIR USE AS OPIOID RECEPTOR LIGANDS | NEUROSEARCH A/S (DK) | 2011-02-24 | — | — | US | disclosed |
| US-20110046180-A1 | N-ARYL-N-PIPERIDIN-4-YL-PROPIONAMIDE DERIVATIVES AND THEIR USE AS OPIOID RECEPTOR LIGANDS | NEUROSEARCH A/S (DK) | 2011-02-24 | — | — | US | disclosed |
| US-20110009449-A1 | N-ARYL-N-PIPERIDIN-4-YL-PROPIONAMIDE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS | NEUROSEARCH A/S (DK) | 2011-01-13 | — | — | US | disclosed |
| US-20110009449-A1 | N-ARYL-N-PIPERIDIN-4-YL-PROPIONAMIDE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS | NEUROSEARCH A/S (DK) | 2011-01-13 | — | — | US | disclosed |
| US-20110009449-A1 | N-ARYL-N-PIPERIDIN-4-YL-PROPIONAMIDE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS | NEUROSEARCH A/S (DK) | 2011-01-13 | — | — | US | disclosed |
| US-20100331367-A1 | N-ARYL-N-PIPERIDIN-4-YL-PROPIONAMIDE DERIVATIVES AND THEIR USE AS OPIOID RECEPTOR LIGANDS | NEUROSEARCH A/S (DK) | 2010-12-30 | — | — | US | disclosed |
| EP-2234972-A1 | N-ARYL-N-PIPERIDIN-4-YL-PROPIONAMIDE DERIVATIVES AND THEIR USE AS OPIOID RECEPTOR LIGANDS | NeuroSearch A/S (DK) | 2010-10-06 | — | — | EP | disclosed |
| EP-2234616-A1 | N-ARYL-N-PIPERIDIN-4-YL-PROPIONAMIDE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS | NeuroSearch A/S (DK) | 2010-10-06 | — | — | EP | disclosed |
| EP-2235006-A1 | N-ARYL-N-PIPERIDIN-4-YL-PROPIONAMIDE DERIVATIVES AND THEIR USE AS OPIOID RECEPTOR LIGANDS | NeuroSearch A/S (DK) | 2010-10-06 | — | — | EP | disclosed |
| WO-2009077574-A1 | N-ARYL-N-PIPERIDIN-4-YL-PROPIONAMIDE DERIVATIVES AND THEIR USE AS OPIOID RECEPTOR LIGANDS | NEUROSEARCH A/S (DK) | 2009-06-25 | — | — | WO | disclosed |
| WO-2009077584-A1 | N-ARYL-N-PIPERIDIN-4-YL-PROPIONAMIDE DERIVATIVES AND THEIR USE AS OPIOID RECEPTOR LIGANDS | NEUROSEARCH A/S (DK) | 2009-06-25 | — | — | WO | disclosed |
| WO-2009077584-A1 | N-ARYL-N-PIPERIDIN-4-YL-PROPIONAMIDE DERIVATIVES AND THEIR USE AS OPIOID RECEPTOR LIGANDS | NEUROSEARCH A/S (DK) | 2009-06-25 | — | — | WO | disclosed |
| WO-2009077585-A1 | N-ARYL-N-PIPERIDIN-4-YL-PROPIONAMIDE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS | NEUROSEARCH A/S (DK) | 2009-06-25 | — | — | WO | disclosed |
| WO-2009077585-A1 | N-ARYL-N-PIPERIDIN-4-YL-PROPIONAMIDE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS | NEUROSEARCH A/S (DK) | 2009-06-25 | — | — | WO | disclosed |
| EP-0708101-B1 | Piperidine derivatives, useful as neurokinin receptor antagonists | ADIR (FR) | 1998-12-09 | — | — | EP | disclosed |
| US-5652246-A | NEUROKININ RECEPTOR ANTAGONISTS; NERVOUS SYSTEM DISORDERS | ADIR ET COMPAGNIE (FR) | 1997-07-29 | — | — | US | disclosed |
| EP-0708101-A1 | Novel piperidine derivatives, useful as neurokinin receptor antagonists | ADIR ET COMPAGNIE (FR) | 1996-04-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110046180-A1 | N-ARYL-N-PIPERIDIN-4-YL-PROPIONAMIDE DERIVATIVES AND THEIR USE AS OPIOID RECEPTOR LIGANDS | OPRL1, OPRD1, OPRK1 | SLC6A4 853/4885TACR1 50/4885SLC6A2 1301/4885 |
| US-20110009449-A1 | N-ARYL-N-PIPERIDIN-4-YL-PROPIONAMIDE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS | SLC18A2, SLC6A2, OPRL1 | SLC6A4 4/4885TACR1 139/4885SLC6A2 2/4885 |
| US-20100331367-A1 | N-ARYL-N-PIPERIDIN-4-YL-PROPIONAMIDE DERIVATIVES AND THEIR USE AS OPIOID RECEPTOR LIGANDS | OPRL1, OPRD1, OPRK1 | SLC6A4 853/4885TACR1 50/4885SLC6A2 1301/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.