Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XDH | P47989 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.38 |
| ▸ | FNTA | P49354 | 1/20 | 0.37 |
| ▸ | FNTB | P49356 | 1/20 | 0.37 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ALDH5A1 | P51649 | 1/20 | 0.34 |
| ▸ | ABAT | P80404 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.33 |
| ▸ | GABBR1 | Q9UBS5 | 1/20 | 0.33 |
| ▸ | WDR5 | P61964 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15783652 | 0.82 | XDH (0.46) | XDHKDM4EPTGS2RAB9AALDH1A1 | |
| SCHEMBL8996225 | 0.79 | ALDH1A1 (0.49) | KDM4EPTGS2ALDH1A1AOX1TRIM24 | |
| SCHEMBL24038842 | 0.77 | PTGS2 (0.55) | XDHKDM4EPTGS2RAB9AALDH1A1 | |
| SCHEMBL30456577 | 0.77 | PTGS2 (0.55) | XDHKDM4EPTGS2RAB9AALDH1A1 | |
| SCHEMBL27935044 | 0.76 | XDH (0.59) | XDHKDM4EPTGS2RAB9AALDH1A1 | |
| SCHEMBL132439 | 0.76 | XDH (0.59) | XDHKDM4EPTGS2RAB9AALDH1A1 | |
| Water SCHEMBL36578 | 0.74 | XDH (0.57) | XDHKDM4EPTGS2RAB9AALDH1A1 | |
| SCHEMBL31122716 | 0.74 | XDH (0.57) | XDHKDM4EPTGS2RAB9AALDH1A1 | |
| SCHEMBL16309120 | 0.74 | SELL (0.54) | KDM4EALDH1A1TDP1ESR1ESR2 | |
| SCHEMBL9248011 | 0.72 | CA1 (0.50) | ALDH1A1HPGDWDR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 46 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9622988-B2 | Small molecule xanthine oxidase inhibitors and methods of use | BAYLOR COLLEGE OF MEDICINE (US) | 2017-04-18 | — | — | US | disclosed |
| US-9622988-B2 | Small molecule xanthine oxidase inhibitors and methods of use | BAYLOR COLLEGE OF MEDICINE (US) | 2017-04-18 | — | — | US | disclosed |
| US-9610257-B2 | Small molecule xanthine oxidase inhibitors and methods of use | BAYLOR COLLEGE OF MEDICINE (US) | 2017-04-04 | — | — | US | disclosed |
| US-9610257-B2 | Small molecule xanthine oxidase inhibitors and methods of use | BAYLOR COLLEGE OF MEDICINE (US) | 2017-04-04 | — | — | US | disclosed |
| US-9585848-B2 | Small molecule xanthine oxidase inhibitors and methods of use | BAYLOR COLLEGE OF MEDICINE (US) | 2017-03-07 | — | — | US | disclosed |
| US-9585848-B2 | Small molecule xanthine oxidase inhibitors and methods of use | BAYLOR COLLEGE OF MEDICINE (US) | 2017-03-07 | — | — | US | disclosed |
| US-9585847-B2 | Small molecule xanthine oxidase inhibitors and methods of use | BAYLOR COLLEGE OF MEDICINE (US) | 2017-03-07 | — | — | US | disclosed |
| US-9585847-B2 | Small molecule xanthine oxidase inhibitors and methods of use | BAYLOR COLLEGE OF MEDICINE (US) | 2017-03-07 | — | — | US | disclosed |
| US-9580379-B2 | Xanthine oxidase inhibitors and methods of use | BAYLOR COLLEGE OF MEDICINE (US) | 2017-02-28 | — | — | US | disclosed |
| US-9580379-B2 | Xanthine oxidase inhibitors and methods of use | BAYLOR COLLEGE OF MEDICINE (US) | 2017-02-28 | — | — | US | disclosed |
| US-8883858-B1 | Small molecule xanthine oxidase inhibitors and methods of use | BAYLOR COLLEGE OF MEDICINE (US) | 2014-11-11 | — | — | US | disclosed |
| US-8883857-B2 | Small molecule xanthine oxidase inhibitors and methods of use | BAYLOR COLLEGE OF MEDICINE (US) | 2014-11-11 | — | — | US | disclosed |
| US-20140329909-A1 | SMALL MOLECULE XANTHINE OXIDASE INHIBITORS AND METHODS OF USE | BAYLOR COLLEGE OF MEDICINE | 2014-11-06 | — | — | US | disclosed |
| US-20140329909-A1 | SMALL MOLECULE XANTHINE OXIDASE INHIBITORS AND METHODS OF USE | BAYLOR COLLEGE OF MEDICINE | 2014-11-06 | — | — | US | disclosed |
| US-20140163045-A1 | Small Molecule Xanthine Oxidase Inhibitors and Methods of Use | BAYLOR COLLEGE OF MEDICINE (US) | 2014-06-12 | — | — | US | disclosed |
| US-20140163045-A1 | Small Molecule Xanthine Oxidase Inhibitors and Methods of Use | BAYLOR COLLEGE OF MEDICINE (US) | 2014-06-12 | — | — | US | disclosed |
| US-5446194-A | Pharmacologically active catechol derivatives | ORION-YHTYMA OY (FI) | 1995-08-29 | — | — | US | disclosed |
| US-5283352-A | Transferase inhibitor | ORION-YHTYMA OY (FI) | 1994-02-01 | — | — | US | disclosed |
| US-5112861-A | Inhibitors of catechol-methyl-transferase enzyme, levodopa | ORION-YHTYMA OY (FI) | 1992-05-12 | — | — | US | disclosed |
| US-4963590-A | ENZYME INHIBITOR FOR TREATING PARKINSON'S DISEASE ALONG WITH DOPA;POTENTIATION | ORION-YHTYMA OY (FI) | 1990-10-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140329909-A1 | SMALL MOLECULE XANTHINE OXIDASE INHIBITORS AND METHODS OF USE | XDH, PNPO, AOX1 | XDH 1/4885KDM4E 3104/4885PTGS2 819/4885 |
| US-20140163045-A1 | Small Molecule Xanthine Oxidase Inhibitors and Methods of Use | XDH, PNPO, AOX1 | XDH 1/4885KDM4E 3104/4885PTGS2 819/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.