Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XDH | P47989 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.48 |
| ▸ | NPC1 | O15118 | 5/20 | 0.48 |
| ▸ | RAB9A | P51151 | 5/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.47 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.47 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | RRM1 | P23921 | 3/20 | 0.44 |
| ▸ | RRM2 | P31350 | 3/20 | 0.44 |
| ▸ | RRM2B | Q7LG56 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9248819 | 1.00 | XDH (0.52) | XDHSMN1; SMN2NPC1RAB9AKMT2A | |
| Hydrochloric Acid SCHEMBL9458934 | 0.85 | RAB9A (0.54) | SMN1; SMN2NPC1RAB9AKMT2ANPSR1 | |
| Hydrochloric Acid SCHEMBL9251283 | 0.85 | RAB9A (0.54) | SMN1; SMN2NPC1RAB9AKMT2ANPSR1 | |
| Hydrochloric Acid SCHEMBL9459226 | 0.81 | XDH (0.53) | XDHSMN1; SMN2NPC1RAB9AKMT2A | |
| Hydrochloric Acid SCHEMBL9251328 | 0.81 | XDH (0.53) | XDHSMN1; SMN2NPC1RAB9AKMT2A | |
| Hydrochloric Acid SCHEMBL9251092 | 0.76 | KMT2A (0.36) | SMN1; SMN2NPC1RAB9AKMT2AL3MBTL1 | |
| Hydrochloric Acid SCHEMBL9287079 | 0.75 | NPC1 (0.50) | XDHSMN1; SMN2NPC1RAB9AKMT2A | |
| Hydrochloric Acid SCHEMBL9287072 | 0.75 | NPC1 (0.50) | XDHSMN1; SMN2NPC1RAB9AKMT2A | |
| SCHEMBL14445009 | 0.72 | KMT2A (0.71) | XDHSMN1; SMN2NPC1RAB9AKMT2A | |
| SCHEMBL1030790 | 0.72 | KMT2A (0.71) | XDHSMN1; SMN2NPC1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5180831-A | Acetylcholinesterase Inhibitors | GEORGIA TECH RESEARCH CORPORATION (US) | 1993-01-19 | — | — | US | disclosed |