Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 2/20 | 0.53 |
| ▸ | HTR2A known ✓ | P28223 | 2/20 | 0.53 |
| ▸ | HTR2C known ✓ | P28335 | 2/20 | 0.53 |
| ▸ | HTR2B known ✓ | P41595 | 2/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.53 |
| ▸ | BCHE | P06276 | 1/20 | 0.53 |
| ▸ | ACHE | P22303 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL9254408 | 1.00 | DRD2 (0.53) | DRD2HTR2AHTR2CHTR2BSIGMAR1 | |
| Fumaric Acid SCHEMBL9256254 | 0.88 | ACHE (0.60) | DRD2HTR2AHTR2CHTR2BSIGMAR1 | |
| Fumaric Acid SCHEMBL9256248 | 0.88 | ACHE (0.60) | DRD2HTR2AHTR2CHTR2BSIGMAR1 | |
| Fumaric Acid SCHEMBL9255821 | 0.87 | ACHE (0.59) | DRD2HTR2AHTR2CHTR2BSIGMAR1 | |
| Fumaric Acid SCHEMBL9255812 | 0.87 | ACHE (0.59) | DRD2HTR2AHTR2CHTR2BSIGMAR1 | |
| Fumaric Acid SCHEMBL9253095 | 0.85 | CCR3 (0.60) | DRD2HTR2AHTR2CHTR2BSIGMAR1 | |
| Fumaric Acid SCHEMBL9253101 | 0.85 | CCR3 (0.60) | DRD2HTR2AHTR2CHTR2BSIGMAR1 | |
| Maleic Acid SCHEMBL467019 | 0.85 | — | — | |
| Fumaric Acid SCHEMBL467020 | 0.85 | — | — | |
| Fumaric Acid SCHEMBL9246842 | 0.84 | KDM4E (0.58) | DRD2HTR2AHTR2CHTR2BSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5441967-A | Treating cerebral edema; anticholinesterase or brain function-improving agent | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1995-08-15 | — | — | US | disclosed |
| US-5294625-A | 1-benzyl,4-((4-dialkylaminophenyl)carbonyl)piperidines | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1994-03-15 | — | — | US | disclosed |
| US-5177087-A | Cerebral edema, cholinesterase inhibitor | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1993-01-05 | — | — | US | disclosed |
| EP-0378207-A1 | Cyclic amine compounds and their use | Takeda Chemical Industries, Ltd. (JP) | 1990-07-18 | — | — | EP | disclosed |