Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 13/20 | 0.43 |
| ▸ | ITGA2B | P08514 | 13/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | F2 | P00734 | 3/20 | 0.39 |
| ▸ | F10 | P00742 | 2/20 | 0.39 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.39 |
| ▸ | ITGAM | P11215 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.39 |
| ▸ | PLG | P00747 | 1/20 | 0.39 |
| ▸ | PLAT | P00750 | 1/20 | 0.39 |
| ▸ | PROC | P04070 | 1/20 | 0.39 |
| ▸ | HPN | P05981 | 1/20 | 0.39 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.39 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.39 |
| ▸ | NQO2 | P16083 | 1/20 | 0.39 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.39 |
| ▸ | SLC47A2 | Q86VL8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9252486 | 0.99 | ITGB3 (0.43) | ITGB3ITGA2BNAMPTF2F10 | |
| SCHEMBL9249665 | 0.90 | TMPRSS15 (0.42) | ITGB3ITGA2BNAMPTF2F10 | |
| SCHEMBL9248776 | 0.87 | NAMPT (0.41) | ITGB3NAMPTHDAC1HDAC8HDAC6 | |
| SCHEMBL9249490 | 0.84 | HDAC1 (0.56) | ITGB3ITGA2BNAMPTF2F10 | |
| SCHEMBL9254738 | 0.84 | ITGB3 (0.41) | ITGB3ITGA2BITGB2ITGAM | |
| SCHEMBL9252708 | 0.82 | CHEK2 (0.51) | ITGB3ITGA2BF2F10HDAC1 | |
| SCHEMBL9254049 | 0.81 | ITGB3 (0.43) | ITGB3ITGA2BF2 | |
| SCHEMBL9252571 | 0.81 | ITGB3 (0.45) | ITGB3ITGA2BNAMPTF2F10 | |
| SCHEMBL9249572 | 0.79 | ITGB3 (0.56) | ITGB3ITGA2BNAMPTF2HDAC1 | |
| SCHEMBL9247795 | 0.79 | ITGB3 (0.44) | ITGB3ITGA2BF2HDAC1HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5434150-A | Anticoagulants, cardiovascular disorders | DR. KARL THOMAE GMBH (DE) | 1995-07-18 | — | — | US | disclosed |
| EP-0531883-A1 | Condensed 5-membered ring heterocycles, process for their preparation and medicaments containing them | Dr. Karl Thomae GmbH (DE) | 1993-03-17 | — | — | EP | disclosed |