Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.37 |
| ▸ | PRSS12 | P56730 | 1/20 | 0.35 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.34 |
| ▸ | ITK | Q08881 | 8/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | GCGR | P47871 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9252454 | 0.87 | PRSS12 (0.38) | PRSS12JAK2JAK1TYK2JAK3 | |
| SCHEMBL9248585 | 0.85 | EGLN1 (0.37) | IRAK4PRSS12EGLN1ITKJAK2 | |
| SCHEMBL9252129 | 0.81 | IRAK4 (0.41) | IRAK4PRSS12EGLN1ITKJAK2 | |
| SCHEMBL9255968 | 0.76 | HDAC1 (0.51) | EGLN1ITKJAK2JAK1TYK2 | |
| SCHEMBL9256882 | 0.74 | CHEK2 (0.38) | PRSS12HDAC3HDAC1HDAC2HDAC8 | |
| Hydrochloric Acid SCHEMBL9246087 | 0.71 | CHEK2 (0.36) | PRSS12HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL9256202 | 0.70 | JAK2 (0.55) | ITKJAK2JAK1TYK2JAK3 | |
| SCHEMBL9250822 | 0.70 | ADORA2A (0.46) | IRAK4EGLN1JAK2JAK1TYK2 | |
| SCHEMBL9245464 | 0.69 | HDAC6 (0.48) | PRSS12HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL9253691 | 0.68 | JAK2 (0.60) | ITKJAK2JAK1TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5434150-A | Anticoagulants, cardiovascular disorders | DR. KARL THOMAE GMBH (DE) | 1995-07-18 | — | — | US | disclosed |
| EP-0531883-A1 | Condensed 5-membered ring heterocycles, process for their preparation and medicaments containing them | Dr. Karl Thomae GmbH (DE) | 1993-03-17 | — | — | EP | disclosed |