Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | ACHE | P22303 | 8/20 | 0.48 |
| ▸ | BCHE | P06276 | 4/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.48 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.46 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9248826 | 0.89 | MAPT (0.60) | MAPTALDH1A1HTTKMT2AACHE | |
| SCHEMBL9248833 | 0.86 | ACHE (0.62) | ALDH1A1LMNAACHEBCHECHRM1 | |
| SCHEMBL9257907 | 0.81 | ACHE (0.65) | ALDH1A1LMNAACHEBCHECHRM1 | |
| SCHEMBL9259735 | 0.78 | ACHE (0.63) | ACHEBCHEGRIN1GRIN2A | |
| SCHEMBL4266767 | 0.78 | ACHE (0.74) | MAPTACHEBCHECHRM1EPHX2 | |
| Hydrochloric Acid SCHEMBL9257228 | 0.77 | ACHE (0.65) | ACHEBCHEGRIN1GRIN2A | |
| SCHEMBL15988214 | 0.77 | ALDH1A1 (0.49) | MAPTALDH1A1HTTKMT2ALMNA | |
| SCHEMBL9255097 | 0.77 | ACHE (0.65) | ACHEBCHECHRM1GRIN1GRIN2A | |
| SCHEMBL9255898 | 0.76 | ACHE (0.47) | MAPTACHEBCHEGRIN1GRIN2A | |
| SCHEMBL29023219 | 0.76 | ACHE (0.73) | MAPTALDH1A1HTTKMT2AACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5391553-A | Increasing cholinergic functionin mammals | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1995-02-21 | — | — | US | disclosed |