Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.67 |
| ▸ | POLB | P06746 | 3/20 | 0.67 |
| ▸ | MAPT | P10636 | 1/20 | 0.67 |
| ▸ | UBE2M | P61081 | 5/20 | 0.62 |
| ▸ | DCUN1D1 | Q96GG9 | 5/20 | 0.62 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.60 |
| ▸ | THRB | P10828 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | USP2 | O75604 | 2/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | CASP3 | P42574 | 1/20 | 0.51 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.51 |
| ▸ | RELA | Q04206 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.51 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.51 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9264006 | 0.90 | ROCK2 (0.61) | TP53POLBMAPTUBE2MDCUN1D1 | |
| SCHEMBL9260282 | 0.85 | DCUN1D1 (0.62) | TP53POLBMAPTUBE2MDCUN1D1 | |
| SCHEMBL9256017 | 0.85 | ALDH1A1 (0.66) | TP53UBE2MDCUN1D1ALDH1A1SMN1; SMN2 | |
| SCHEMBL9263254 | 0.84 | ALDH1A1 (0.53) | TP53POLBMAPTUBE2MDCUN1D1 | |
| SCHEMBL9257513 | 0.83 | THRB (0.50) | TP53POLBMAPTUBE2MDCUN1D1 | |
| SCHEMBL10587275 | 0.83 | DCUN1D1 (0.61) | TP53POLBMAPTUBE2MDCUN1D1 | |
| Hydrochloric Acid SCHEMBL9260026 | 0.83 | ALDH1A1 (0.52) | TP53POLBMAPTUBE2MDCUN1D1 | |
| Hydrochloric Acid SCHEMBL9256917 | 0.82 | DCUN1D1 (0.60) | TP53POLBMAPTUBE2MDCUN1D1 | |
| SCHEMBL9262760 | 0.82 | LMNA (0.59) | TP53POLBMAPTUBE2MDCUN1D1 | |
| SCHEMBL9257297 | 0.81 | DCUN1D1 (0.56) | TP53MAPTUBE2MDCUN1D1ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5384425-A | Diurea derivatives useful as medicaments and processes for the preparation thereof | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1995-01-24 | — | — | US | disclosed |
| EP-0325397-B1 | DIUREA DERIVATIVES USEFUL AS MEDICAMENTS AND PROCESSES FOR THE PREPARATION THEREOF | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1993-08-18 | — | — | EP | disclosed |
| US-5166429-A | Enzyme inhibitors of acylcoenzyme A cholesterol transferase as anticholesterol agents or antideposit agents | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1992-11-24 | — | — | US | disclosed |
| US-5091419-A | Anticholesterol agent | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1992-02-25 | — | — | US | disclosed |