Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | F2RL1 | P55085 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.38 |
| ▸ | MITF | O75030 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8356513 | 0.88 | KMT2A (0.54) | L3MBTL1KMT2AMEN1POLBALDH1A1 | |
| SCHEMBL31757297 | 0.87 | KMT2A (0.45) | L3MBTL1KMT2AMEN1POLBALDH1A1 | |
| SCHEMBL29116794 | 0.82 | L3MBTL1 (0.57) | L3MBTL1KMT2AMEN1EPHX2NPSR1 | |
| SCHEMBL8356511 | 0.80 | KMT2A (0.60) | L3MBTL1KMT2AMEN1EPHX2NPSR1 | |
| SCHEMBL10339219 | 0.76 | CA2 (0.54) | LMNAPOLBALDH1A1MAPK1NPC1 | |
| SCHEMBL8356508 | 0.74 | KMT2A (0.55) | L3MBTL1KMT2AMEN1EPHX2NPSR1 | |
| SCHEMBL11626650 | 0.72 | MAP4K4 (0.57) | KMT2AMEN1MAP4K4ALDH1A1NPC1 | |
| SCHEMBL7557354 | 0.70 | PLA2G2A (0.53) | LMNAALDH1A1NPC1KDM4ERAB9A | |
| SCHEMBL19444606 | 0.69 | CCR5 (0.64) | L3MBTL1KMT2AMEN1MAP4K4EPHX2 | |
| SCHEMBL11194417 | 0.69 | S1PR1 (0.47) | KMT2AMEN1EPHX2LMNANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5384425-A | Diurea derivatives useful as medicaments and processes for the preparation thereof | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1995-01-24 | — | — | US | disclosed |
| EP-0325397-B1 | DIUREA DERIVATIVES USEFUL AS MEDICAMENTS AND PROCESSES FOR THE PREPARATION THEREOF | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1993-08-18 | — | — | EP | disclosed |
| US-5166429-A | Enzyme inhibitors of acylcoenzyme A cholesterol transferase as anticholesterol agents or antideposit agents | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1992-11-24 | — | — | US | disclosed |
| US-5091419-A | Anticholesterol agent | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1992-02-25 | — | — | US | disclosed |