Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 6/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | CCR2 | P41597 | 1/20 | 0.43 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.40 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | FADS1 | O60427 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28174251 | 0.83 | CCR2 (0.41) | HSD11B1MEN1KMT2ARAB9ANPC1 | |
| SCHEMBL21333901 | 0.77 | HSD11B1 (0.39) | HSD11B1MEN1KMT2ARAB9ANPC1 | |
| SCHEMBL31687681 | 0.75 | MAPT (0.48) | HSD11B1MEN1KMT2ARAB9ANPC1 | |
| SCHEMBL15542071 | 0.75 | PARP1 (0.46) | HSD11B1ALDH1A1CCR2HCAR3HCAR2 | |
| SCHEMBL301985 | 0.74 | MEN1 (0.56) | HSD11B1MEN1KMT2ARAB9ANPC1 | |
| SCHEMBL30424283 | 0.72 | SLC6A3 (0.45) | HSD11B1MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL3110960 | 0.71 | AKR1C1 (0.65) | HSD11B1MEN1KMT2ACCR2SLC6A4 | |
| SCHEMBL9466663 | 0.71 | AKR1C1 (0.59) | HSD11B1MEN1KMT2ACCR2HCAR3 | |
| Benzene SCHEMBL28354853 | 0.70 | HDAC4 (0.41) | HSD11B1KMT2ALMNAHTT | |
| SCHEMBL27498742 | 0.70 | HCAR3 (0.41) | HSD11B1MEN1KMT2ARAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0490772-B1 | 1,4-Disubstituted piperazines, their process of preparation and pharmaceutical compositions containing them | ADIR (FR) | 1995-07-26 | — | — | EP | disclosed |
| EP-0490772-A1 | 1,4-Disubstituted piperazines, their process of preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1992-06-17 | — | — | EP | disclosed |