Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 6/20 | 0.47 |
| ▸ | GPR34 | Q9UPC5 | 1/20 | 0.46 |
| ▸ | ACE | P12821 | 5/20 | 0.46 |
| ▸ | CPA1 | P15085 | 4/20 | 0.46 |
| ▸ | ACE2 | Q9BYF1 | 4/20 | 0.46 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.45 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.45 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.45 |
| ▸ | ITGAV | P06756 | 1/20 | 0.45 |
| ▸ | CTSC | P53634 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.43 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.43 |
| ▸ | NAALAD2 | Q9Y3Q0 | 1/20 | 0.43 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | FPR1 | P21462 | 2/20 | 0.42 |
| ▸ | FPR2 | P25090 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5435243 | 0.85 | CTSS (0.56) | MMEGPR34ACECPA1ACE2 | |
| SCHEMBL5435245 | 0.85 | CTSS (0.56) | MMEGPR34ACECPA1ACE2 | |
| SCHEMBL7292657 | 0.85 | CTSS (0.56) | MMEGPR34ACECPA1ACE2 | |
| SCHEMBL22285670 | 0.82 | ITGB3 (0.52) | MMEGPR34ACECPA1ACE2 | |
| SCHEMBL22285669 | 0.82 | ITGB3 (0.52) | MMEGPR34ACECPA1ACE2 | |
| SCHEMBL28357222 | 0.81 | LOXL2 (0.49) | MMEGPR34ACECPA1ACE2 | |
| SCHEMBL29855080 | 0.81 | LOXL2 (0.49) | MMEGPR34ACECPA1ACE2 | |
| SCHEMBL5490779 | 0.81 | FOLH1 (0.61) | MMEACECPA1ACE2FOLH1 | |
| SCHEMBL20578232 | 0.81 | CA2 (0.58) | MMEACECPA1ACE2ITGB3 | |
| SCHEMBL5851226 | 0.81 | FOLH1 (0.61) | MMEACECPA1ACE2FOLH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5412145-A | P2'-modified hydroxamic acid collagenase inhibitors | BRITISH BIO-TECHNOLOGY LIMITED (GB) | 1995-05-02 | — | — | US | disclosed |
| US-5300674-A | P2'-modified hydroxamic acid collagenase inhibitors | BRITISH BIO-TECHNOLOGY LIMITED (GB) | 1994-04-05 | — | — | US | disclosed |