Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.30 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10147277 | 0.71 | HSD11B1 (0.30) | — | |
| SCHEMBL14278564 | 0.68 | TSHR (0.37) | LMNA | |
| SCHEMBL1474193 | 0.67 | TSHR (0.43) | LMNAKMT2A | |
| SCHEMBL1474192 | 0.67 | TSHR (0.43) | LMNAKMT2A | |
| SCHEMBL9249537 | 0.66 | LMNA (0.36) | LMNAGAAHTTHRH3 | |
| SCHEMBL17995482 | 0.64 | LMNA (0.31) | LMNA | |
| SCHEMBL13482601 | 0.63 | LMNA (0.30) | LMNA | |
| SCHEMBL5276863 | 0.62 | MAPK1 (0.33) | — | |
| SCHEMBL10303795 | 0.60 | PRKCA (0.39) | LMNA | |
| SCHEMBL17995472 | 0.60 | TSHR (0.43) | LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0311313-B1 | Heterocyclic spiro compounds and their preparation | YAMANOUCHI PHARMA CO LTD (JP) | 1995-05-10 | — | — | EP | disclosed |
| US-5412096-A | Treatment of senile dementia, Alzheimer*s disease, cholinergic activators | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1995-05-02 | — | — | US | disclosed |
| US-5041549-A | Cholinergin agents | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1991-08-20 | — | — | US | disclosed |
| US-4996210-A | Cognition activators, nervous system disorders; muscarinic acetylcholine receptor agonists; 2,8-dimethyl-3-methylene-1-oxa-8-azaspiro[4.5]decane for example | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1991-02-26 | — | — | US | disclosed |
| EP-0311313-A2 | Heterocyclic spiro compounds and their preparation | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1989-04-12 | — | — | EP | disclosed |