Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 9/20 | 0.37 |
| ▸ | HTR1D | P28221 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.35 |
| ▸ | PRKACA | P17612 | 1/20 | 0.35 |
| ▸ | PRKACG | P22612 | 1/20 | 0.35 |
| ▸ | PRKACB | P22694 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15133163 | 0.87 | CYP3A4 (0.46) | CYP3A4CASP1RECQLALDH1A1CA12 | |
| SCHEMBL2718795 | 0.83 | CYP3A4 (0.42) | CYP3A4CASP1RECQLALDH1A1CA12 | |
| SCHEMBL21377671 | 0.83 | CYP3A4 (0.42) | CYP3A4CASP1RECQLALDH1A1CA12 | |
| SCHEMBL3647735 | 0.81 | CYP3A4 (0.41) | CYP3A4CASP1RECQLALDH1A1CA12 | |
| SCHEMBL6257993 | 0.81 | CYP3A4 (0.41) | CYP3A4CASP1RECQLALDH1A1CA12 | |
| SCHEMBL9219871 | 0.80 | OPRD1 (0.44) | CYP3A4ALOX5HTR1DALDH1A1CA12 | |
| SCHEMBL1193696 | 0.79 | OPRM1 (0.52) | ALOX5HTR1DOPRM1OPRD1OPRK1 | |
| SCHEMBL932071 | 0.79 | CHRNA1 (0.42) | ALOX5HTR1DALDH1A1OPRM1OPRD1 | |
| SCHEMBL9429709 | 0.79 | ALOX5 (0.37) | ALOX5HTR1DCYP11B1CYP11B2HRH3 | |
| SCHEMBL1598578 | 0.79 | ALOX5 (0.37) | ALOX5HTR1DCYP11B1CYP11B2HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2221051-A1 | AMINE DERIVATIVE HAVING NPY Y5 RECEPTOR ANTAGONIST ACTIVITY AND USE THEREOF | Shionogi&Co., Ltd. (JP) | 2010-08-25 | — | — | EP | disclosed |
| EP-2014285-B1 | NPYY5 antagonists | SHIONOGI & CO (JP) | 2010-05-05 | — | — | EP | disclosed |
| EP-2017261-A1 | AMINE DERIVATIVE HAVING NPY Y5 RECEPTOR ANTAGONIST ACTIVITY | SHIONOGI & CO., LTD. (JP) | 2009-01-21 | — | — | EP | disclosed |
| US-5432194-A | Antiallergens, antinflammatory agents | ABBOTT LABORATORIES (US) | 1995-07-11 | — | — | US | disclosed |
| WO-1994026264-A1 | (4-ALKOXYPYRAN-4-YL) SUBSTITUTED ARYLALKYLARYL-, ARYLALKENYLARYL-, AND ARYLALKYNYLARYLUREA INHIBITORS OF 5-LIPOXYGENASE | ABBOTT LABORATORIES (US) | 1994-11-24 | — | — | WO | disclosed |
| US-5346914-A | Antiallergens, antiinflammatory agents | ABBOTT LABORATORIES (US) | 1994-09-13 | — | — | US | disclosed |