Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 13/20 | 0.37 |
| ▸ | HTR1D | P28221 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.33 |
| ▸ | PDE2A | O00408 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9219871 | 0.80 | OPRD1 (0.44) | ALOX5HTR1DOPRM1OPRD1OPRK1 | |
| SCHEMBL9258923 | 0.79 | CYP3A4 (0.38) | ALOX5HTR1DHRH3CYP11B1CYP11B2 | |
| SCHEMBL932071 | 0.79 | CHRNA1 (0.42) | ALOX5HTR1DOPRM1OPRD1OPRK1 | |
| SCHEMBL1598578 | 0.79 | ALOX5 (0.37) | ALOX5HTR1DHRH3CYP11B1CYP11B2 | |
| SCHEMBL1193696 | 0.79 | OPRM1 (0.52) | ALOX5HTR1DOPRM1OPRD1OPRK1 | |
| SCHEMBL1255944 | 0.77 | OPRL1 (0.52) | HRH3OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL19701990 | 0.75 | OPRM1 (0.43) | ALOX5HTR1DOPRM1OPRD1OPRK1 | |
| SCHEMBL9430065 | 0.75 | ALOX5 (0.51) | ALOX5 | |
| SCHEMBL22290862 | 0.70 | LIPG (0.42) | ALOX5HTR1D | |
| SCHEMBL9208096 | 0.69 | ALOX5 (0.48) | ALOX5OPRM1OPRD1OPRK1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5362878-A | Intermediates for making N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase (ACAT) | PFIZER INC. (US) | 1994-11-08 | — | — | US | disclosed |
| WO-1994011378-A1 | ARYL THIOPYRANO[2,3,4-c,d]INDOLES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | MERCK FROSST CANADA INC. (CA) | 1994-05-26 | — | — | WO | disclosed |
| US-5314900-A | Aryl thiopyrano[2,3,4-C,D]indoles as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA, INC. (CA) | 1994-05-24 | — | — | US | disclosed |